Browsing Research publications by Author "Extracellular Vesicle Research Unit"
Now showing items 41-60 of 151
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Distribution of Surgical Smoke Particles within a Simulated Laparoscopic Cavity Utilizing an AirSeal® System
Lathers, Steven; Krishnamoorthy, Mahesh; Vasdev, Nikhil; Tegan, Gary (2022-07-08)An exploratory study was performed to determine the distribution of surgical smoke particulate matter (SSPM) and evacuation times within an AirSeal® System and a traditional insufflation access system in various simulated ... -
Dual independent displacement-amplified micropumps with a single actuator
Tracey, M.C.; Johnston, I. D.; Davis, J. B.; Tan, C. K. L. (2006-08)We report a dual-micropump structure operated by a single actuator element. The constituent micropumps are a form of micro throttle pump (MTP) comprising a narrow flow channel incorporating two microthrottles. We term this ... -
Editorial: Microbial interactions of Clostridioides difficile
Goh, Shan; Mullany, Peter; Riley, Thomas V. (2023-01-06) -
Effect of Robot-Assisted Radical Cystectomy with Intracorporeal Urinary Diversion versus Open Radical Cystectomy on 90 day Morbidity Among Patients with Bladder Cancer - A Randomized Clinical Trial
Catto, James W F; Khetrapal, Pramit; Ricciardi , Federico; Ambler, Gareth; Khan, Shamim; Nair, Raj; Feber, Andrew; Dixon, Simon; Williams, Norman; Nathan, Senthil; Briggs, Tim; Sridhar, Ashwin; Ahmed, Imram; Bhatt, Jaimin; Charlesworth, Philip; Cumberbatch, Marcus; Hussain, Syed A.; Kotwal, Sanjeev; Koupparis, Anthony; McGrath, John; Noon, Aidan; Rowe, Edward; Vasdev, Nikhil; Hanchale, Vishwanath; Hagan, Daryl; Bew-Graves, Chris; Kelly, John D (2022-05-15)Importance Robot-assisted radical cystectomy is being performed with increasing frequency, but it is unclear whether total intracorporeal surgery improves recovery compared with open radical cystectomy for bladder cancer. ... -
Effects of delayed radical prostatectomy and active surveillance on localised prostate cancer - A systematic review and meta-analysis
Chan, Vinson Wai-Shun; Tan, Wei Shen; Asif, Aqua; Ng, Alexander; Gbolahan, Olayinka; Dinneen, Eion; To, Wilson; Kadhim, Hassan; Premchand, Melissa; Burton, Oliver; Koe, Jasmine Sze-Ern; Wang, Nicole; Leow, Jeffrey; Giannarini, Gianluca; Vasdev, Nikhil; Shariat, Shahrokh F; Enikeev, Dmitry; Ng, Chi Fai; Teoh, Jeremy Yeun-Chun (2021-06-30)External factors, such as the coronavirus disease 2019 (COVID-19), can lead to cancellations and backlogs of cancer surgeries. The effects of these delays are unclear. This study summarised the evidence surrounding expectant ... -
Elastomer-glass micropump employing active throttles
Johnston, I. D.; Davis, J.B.; Richter, R.; Herbert, G. I.; Tracey, M.C. (2004)We report a reciprocating microfluidic pump, the Micro Throttle Pump (MTP), constructed in a relatively uncomplicated manner from glass and microstructured poly(dimethylsiloxane) (PDMS). Unconventionally, the MTP employs ... -
Electrowetting-Based Digital Microfluidics Platform for Automated Enzyme-linked Immunosorbent Assay
Dimov, Nikolay; McDonnell, M.B.; Munro, Ian; McCluskey, Daniel; Johnston, Ian; Tan, Christabel; Coudron, Loic (2020-02-23)Electrowetting is the effect by which the contact angle of a droplet exposed to a surface charge is modified. Electrowetting-on-dielectric (EWOD) exploits the dielectric properties of thin insulator films to enhance the ... -
The emerging role of Artificial Intelligence in the fight against COVID-19
Ghose, Aruni; Roy, Sabyasachi; Olsburgh, Jonathon; Vasdev, Nikhil; Dasgupta, Prokar (2020-09-17)The coronavirus disease 2019 (COVID-19) pandemic has generated large volumes of clinical data that can be an invaluable resource towards answering a number of important questions for this and future pandemics. Artificial ... -
Epiboly generates the epidermal basal monolayer and spreads the nascent mammalian skin to enclose the embryonic body
Panousopoulou, Eleni; Hobbs, Carl; Mason, Ivor; Green, Jeremy B A; Formstone, Caroline J (2016-05-01)Epiboly is a morphogenetic process that is employed in the surface ectoderm of anamniotes during gastrulation to cover the entire embryo. We propose here that mammals also utilise this process to expand the epidermis and ... -
Erdafitinib in BCG-treated high risk non-muscle invasive bladder cancer
Catto, James W.F.; Tran, Ben; Roupret, Morgan; Gschwend, Juergen E.; Loriot, Yohann; Nishiyama, Hiroyuki; Redorta, Joan P.; Daneshmand, Siamak; Hussain, Syed A.; Cutuli, Hernan J; Procopio, Giuseppe; Guadalupi, Valentina; Vasdev, Nikhil; Naini, Vahid; Crow, Lauren; Triantos, Spyros; Baig, Mahadi; Steinberg, Gary D. (2024-01-30)Background: Treatment options are limited for patients with high-risk non-muscle-invasive bladder cancer (NMIBC) with disease recurrence after bacillus Calmette–Guérin (BCG) treatment and who are ineligible for/refuse ... -
Exploitation of antimicrobial nanoparticles and their applications in biomedical engineering
Cheong, Yuen Ki; Ren, Guogang; Chung, Etelka; Yang, Xiuyi; Johnston, Ian (2021-05-15)Antibiotic resistance is a major threat to public health which contributes largely to increased mortality rates and costs in hospitals. The severe and wide spread of antibiotic resistance results in limited treatment to ... -
Fully integrated digital microfluidics platform for automated immunoassay; a versatile tool for rapid, specific detection of a wide range of pathogens
Coudron, Loic; McDonnell, M.B.; Munro, Ian; McCluskey, Daniel; Johnston, Ian; Tan, Christabel; Tracey, Mark (2019-03-01)With the tangible threat posed by the release of chemical and biological warfare (CBW) agents, detection of airborne pathogens is a critical military and security concern. Recent air sampling techniques developed for ... -
The future of robotic surgery
Brodie, Andrew; Vasdev, Nikhil (2018-09-01)For 20 years Intuitive Surgical’s da Vinci® system has held the monopoly in minimally invasive robotic surgery. Restrictive patenting, a well-developed marketing strategy and a high-quality product have protected the ... -
Genetic modifiers ameliorate endocytic and neuromuscular defects in a model of spinal muscular atrophy
Walsh, Melissa B.; Janzen, Eva; Wingrove, Emily; Hosseinibarkooie, Seyyedmohsen; Rodriguez Muela, Natalia; Davidow, Lance; Dimitriadi, Maria; M. Norabuena, Erika; L Rubin, Lee; Wirth, Brunhilde; C. Hart, Anne (2020-09-16)Background: Understanding the genetic modifiers of neurodegenerative diseases can provide insight into the mechanisms underlying these disorders. Here, we examine the relationship between the motor neuron disease spinal ... -
Genomic evidence for genes encoding leucine-rich repeat receptors linked to resistance against the eukaryotic extra- and intracellular Brassica napus pathogens Leptosphaeria maculans and Plasmodiophora brassicae
Stotz, Henrik; Pascoe, Harvey; Parham, Haddadi; Fitt, Bruce; Mashanova, Alla; Kukol, Andreas; Larkan, Nicholas; Hossein, Borhan (2018-06-01)Genes coding for nucleotide-binding leucine-rich repeat (LRR) receptors (NLRs) control resistance against intracellular (cell-penetrating) pathogens. However, evidence for a role of genes coding for proteins with LRR domains ... -
Global Trends of Prostate Cancer by Age, and Their Associations with Gross Domestic Product (GDP), Human Development Index (HDI), Smoking, and Alcohol Drinking
Huang, Junjie; Chan, Erica On-Ting; Liu, Xianjing; Lok, Veeleah; Ngai, Chun Ho; Zhang, Lin; Xu, Wanghong; Zheng, Zhi-Jie; Chiu, Peter Ka-Fung; Vasdev, Nikhil; Enikeev, Dmitry; Shariat, Shahrokh F.; Ng, Chi-Fai; Teoh, Jeremy Yuen-Chun; Wong, Martin CS (2023-08-30)Background: We aimed to examine the global disease burden and trends of prostate cancer incidence and mortality by age, and their associations with gross domestic product (GDP), human development index (HDI), smoking, and ... -
Guideline of Guidelines: Muscle Invasive Bladder Cancer
Omorphos, Nicolas; Pansaon Piedad, John Carlo; Vasdev, Nikhil (2020-09-21)Muscle-invasive bladder cancer accounts for 25% of bladder cancer cases and represents a spectrum of disease, which can result in significant morbidity and mortality for anyone affected. Current management has evolved ... -
Has robotic prostatectomy determined the fall of the laparoscopic approach?
Hayes, John; Vasdev, Nikhil; Dasgupta, Prokar (2021-12-25)Robotic Assisted Laparoscopic Prostatectomy (RALP) has revolutionised the surgical management of localised Prostate Cancer in the modern era. The surgeon is provided with greater precision, more versatile dexterity and an ... -
Identification of Theileria lestoquardi Antigens Recognized by CD8+ T Cells
Goh, Shan; Ngugi, Daniel; Lizundia, Regina; Hostettler, Isabel; Woods, Kerry; Ballingall, Keith; MacHugh, Niall D; Morrison, W Ivan; Weir, Willie; Shiels, Brian; Werling, Dirk (2016-09-09)As part of an international effort to develop vaccines for Theileria lestoquardi, we undertook a limited screen to test T. lestoquardi orthologues of antigens recognised by CD8+ T lymphocyte responses against T. annulata ... -
Immunotherapy in Urological Tumors
Sharma, Anand; Suleyman, Narin M.; Vasdev, Nikhil; Jones, Oliver (2019)The past decade has seen significant improvement in our understanding of tumor biological features, which has led to use of anti-programmed-death 1 (PD-1) and anti-PDligand-1 (PD-L1) agents and cytotoxic T lymphocytes ...