Browsing Research publications by Author "Cook, Michael T."
Now showing items 1-20 of 33
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Chitosan coated alginate beads for the survival of microencapsulated Lactobacillus plantarum in pomegranate juice
Nualkaekul, Sawaminee; Lenton, Dominique; Cook, Michael T.; Khutoryanskiy, Vitaliy V.; Charalampopoulos, Dimitris (2012-10-15)This work studied the effect of multi-layer coating of alginate beads on the survival of encapsulated Lactobacillus plantarum in simulated gastric solution and during storage in pomegranate juice at 4°C. Uncoated, single ... -
CLSM method for the dynamic observation of pH change within polymer matrices for oral delivery
Cook, Michael T.; Saratoon, Teedah; Tzortzis, George; Edwards, Alexander; Charalampopoulos, Dimitris; Khutoryanskiy, Vitaliy V. (2013-02-11)If acid-sensitive drugs or cells are administered orally, there is often a reduction in efficacy associated with gastric passage. Formulation into a polymer matrix is a potential method to improve their stability. The ... -
Combining branched copolymers with additives generates stable thermoresponsive emulsions with in situ gelation upon exposure to body temperature
Rajbanshi, Abhishek; Mahmoudi, Najet; Murnane, Darragh; Pavlova, Ewa; Slouf, Miroslav; Dreiss, Cécile A.; Cook, Michael T. (2023-04-04)Branched copolymer surfactants (BCS) containing thermoresponsive polymer components, hydrophilic components, and hydrophobic termini allow the formation of emulsions which switch from liquid at room temperature to a gel ... -
A Design-of-Experiments Approach to Developing Thermoresponsive Gelators From Complex Polymer Mixtures
Kirton, Stewart; Stair, Jacqueline; Abou Shamat, Mohamad; Calvo-Castro, Jesus; Cook, Michael T. (2020-10-13)This study investigated the effects of additives on the properties of poloxamer (P) 407 thermogels, employing a design-of-experiments (DoE) approach. P407 is a thermoresponsive triblock copolymer that exhibits a solution ... -
The effect of erythrosine-B on the structuration of poloxamer 407 and cellulose derivative blends: in silico modelling supporting experimental studies
da Silva, Jéssica Bassi; da Silva Souza Campanholi, Katieli; Braga, Gustavo; de Souza, Paulo Ricardo; Caetano, Wilker; Cook, Michael T.; Bruschi, Marcos Luciano (2021-11-30)Erythrosine is a dye approved for medical use that has shown promising photodynamic activity, allowing for the inactivation of microorganisms and activity against malignant cells. Despite the great photodynamic potential, ... -
Engineering thermoresponsive emulsions with branched copolymer surfactants
Cook, Michael T.; Rajbanshi, Abhishek; Achampong, Daniel; Dreiss, Cécile A.; Alves da Silva, Marcelo; Porcar, Lionel; Mahmoudi, Najet; Maestro, Armando; Tummino, Andrea; Gutfreund, Philipp (2022-10-30)This study describes thermo‐rheological properties of branched copolymer surfactants (BCSs) stabilizing oil‐in‐water emulsions to generate materials exhibiting temperature‐dependent gelation with the ability to solubilize ... -
In situ gelling drug delivery systems for topical drug delivery
Cook, Michael T.; Kolawole, Oluwadamilola (2023-01-13)In situ gelling formulations are drug delivery systems which typically exist in a liquid form at room temperature and change into gel state after application to the body in response to various stimuli such as changes in ... -
In Vitro Cell Models for Ophthalmic Drug Development Applications
Shafaie, Sara; Hutter, Victoria; Cook, Michael T.; Brown, Marc; Chau, David Y.S. (2016-04-20)Tissue engineering is a rapidly expanding field that aims to establish feasible techniques to fabricate biologically equivalent replacements for diseased and damaged tissues/organs. Emerging from this prospect is the ... -
Influence of encapsulation and coating materials on the survival of Lactobacillus plantarum and Bifidobacterium longum in fruit juices
Nualkaekul, Sawaminee; Cook, Michael T.; Khutoryanskiy, Vitaliy V.; Charalampopoulos, Dimitris (2013-08-01)The aim of this work was to compare alginate and pectin beads for improving the survival of Lactobacillus plantarum and Bifidobacterium longum during storage in pomegranate and cranberry juice, and to evaluate the influence ... -
Interaction between mucoadhesive cellulose derivatives and Pluronic F127: investigation on the micelle structure and mucoadhesive performance
Cook, Michael T.; da Silva, Jéssica Bassi; Bruschi, Marcos Luciano (2020-10-17)Systems composed of bioadhesive and thermoresponsive polymers can combine in situ gelation with bio/mucoadhesion, enhancing retention of topically applied drugs. The effect of bioadhesive sodium carboxymethylcellulose ... -
Investigation of milk proteins binding to the oral mucosa
Withers, Caroline A.; Cook, Michael T.; Methven, Lisa; Gosney, Margot A.; Khutoryanskiy, Vitaliy V. (2013-11-01)High protein dairy beverages are considered to be mouth drying. The drying sensation may be due to the product protein content; however the mechanism of this mouth drying is uncertain. This study investigated the potential ... -
Layer-by-layer coating of alginate matrices with chitosan-alginate for the improved survival and targeted delivery of probiotic bacteria after oral administration
Cook, Michael T.; Tzortzis, George; Khutoryanskiy, Vitaliy V.; Charalampopoulos, Dimitris (2013-01-07)The oral administration of probiotic bacteria has shown potential in clinical trials for the alleviation of specific disorders of the gastrointestinal tract. However, cells must be alive in order to exert these benefits. ... -
Microencapsulation of a synbiotic into PLGA/alginate multiparticulate gels
Cook, Michael T.; Tzortzis, George; Charalampopoulos, Dimitris; Khutoryanskiy, Vitaliy V. (2014-05-15)Probiotic bacteria have gained popularity as a defence against disorders of the bowel. However, the acid sensitivity of these cells results in a loss of viability during gastric passage and, consequently, a loss of efficacy. ... -
Microencapsulation of probiotic bacteria into alginate hydrogels
Cook, Michael T.; Charalampopoulos, D.; Khutoryanskiy, V. V. (Royal Society of Chemistry, 2014-04-14) -
Microencapsulation of probiotics for gastrointestinal delivery
Cook, Michael T.; Tzortzis, George; Charalampopoulos, Dimitris; Khutoryanskiy, Vitaliy V. (2012-08-20)The administration of probiotic bacteria as nutraceuticals is an area that has rapidly expanded in recent years, with a global market worth $32.6 billion predicted by 2014. Many of the health promoting claims attributed ... -
Mitochondrial Targeting and Imaging with Small Organic Conjugated Fluorophores: A Review
Bassin, Jatinder; Dimitriadi, Maria; Cook, Michael T.; Abelha, Thais Fedatto; Calvo-Castro, Jesus (2022-12-27)Abstract: The last decade has seen an increasingly large number of studies reporting on the development of novel small organic conjugated systems for mitochondrial imaging exploiting optical signal transduction pathways. ... -
Mucoadhesion and mucosa-mimetic materials - a mini-review
Cook, Michael T.; Khutoryanskiy, Vitaliy V. (2015-11-30)Mucoadhesion describes an attractive interaction between dosage form and mucosal membrane. The evaluation of mucoadhesive excipients often requires the use of ex vivo mucosal tissues taken from laboratory animals. These ... -
Novel glycopolymer hydrogels as mucosa-mimetic materials to reduce animal testing
Cook, Michael T.; Smith, Sarah L.; Khutoryanskiy, Vitaliy V. (2015-07-21)Glycopolymer hydrogels capable of mimicking mucosal tissue in mucoadhesion testing have been designed. Liquid formulations containing mucoadhesive polymers were found to be retained on these tissues to the same extent as ... -
Optimising poly(lactic-co-glycolic acid) microparticle fabrication using a Taguchi orthogonal array design-of-experiment approach
Mensah, Rosemond; Kirton, Stewart; Cook, Michael T.; Styliari, Ioanna Danai; Hutter, Victoria; Chau, David (2019-09-26)The objective of this study was to identify, understand and generate a Taguchi orthogonal array model for the formation of 10–50 μm microparticles with applications in topical/ocular controlled drug delivery. Poly(lactic ... -
The permeability of human eyelid skin to topically applied lidocaine
Emeriewen, K.; McAuley, William; Beebeejaun, Mubinah; Cook, Michael T.; Saleh, G.M. (2020-02-01)This work investigated the permeability of lidocaine across human eyelid skin and compared this with published data for abdominal skin to understand the characteristics of this type of skin and whether topical anaesthesia ...