Browsing Research publications by Author "Gibbons, S."
Now showing items 1-12 of 12
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2β-Acetoxyferruginol - A new antibacterial abietane diterpene from the bark of Prumnopitys andina
Smith, E.C.J.; Gibbons, S.; Wareham, N.; Zloh, Mire (2008-04-15)As part of an on-going project to isolate antibacterial compounds from rare conifer species, a new abietane diterpene, 2β-acetoxyferruginol was isolated from the stem bark of Prumnopitys andina. Molecular modelling studies ... -
Amanicadol, a pimarane-type diterpene from Phlomis amanica Vierch
Yalçin, F.N.; Ersöz, T.; Çaliş, I.; Bedir, E.; Dönmez, A.A.; Stavri, M.; Gibbons, S.; Zloh, Mire (2006-11-01)Fractionation of the methanol extract of Phlomis amanica resulted in the isolation of a new pimarane type diterpene, amanicadol (1), together with the known glycosides lamiide, verbascoside (= acteoside), syringaresinol-4-O-β- ... -
Aryldiketo acids have antibacterial activity against MDR Staphylococcus aureus strains : Structural insights based on similarity and molecular interaction fields
Drakulić, B.J.; Stavri, M.; Gibbons, S.; Žižak, Ž.S.; Verbić, T.Ž.; Juranić, I.O.; Zloh, Mire (2009-12-07)(Chemical Equation Presented) Similar structure=similar activity? The effect of substituents on the antibacterial activity of aryldiketo acids has been rationalised by molecular interaction fields and similarity studies ... -
In silico screening for antibiotic escort molecules to overcome efflux
Rahman, S.S.; Simovic, I.; Gibbons, S.; Zloh, Mire (2011-11-01)Resistance to antibiotics is a growing problem worldwide and occurs in part due to the overexpression of efflux pumps responsible for the removal of antibiotics from bacterial cells. The current study examines complex ... -
In Silico Screening of Escort Molecules that Complex with Antibiotics
Rahman, S.S.; Gibbons, S.; Zloh, Mire (2010-10) -
Inhibitors of multidrug resistance (MDR) have affinity for MDR substrates
Zloh, Mire; Kaatz, G.W.; Gibbons, S. (2004-02-23)Multidrug-resistance (MDR) occurs in many bacterial species and tumour cells. MDR functions by membrane proteins which export drugs from cells, resulting in a low ineffective concentration of the drug. We have shown by ... -
Molecular similarity of MDR inhibitors
Zloh, Mire; Gibbons, S. (2004-02-01)The molecular similarity of multidrug resistance (MDR) inhibitors was evaluated using the point centred atom charge approach in an attempt to find some common features of structurally unrelated inhibitors. A series of ... -
Near-infrared spectroscopy (NIRS) and chemometric analysis of Malaysian and UK paracetamol tablets : A spectral database study
Said, M.M.; Gibbons, S.; Moffat, A.C.; Zloh, Mire (2011-08-30)The influx of medicines from different sources into healthcare systems of developing countries presents a challenge to monitor their origin and quality. The absence of a repository of reference samples or spectra prevents ... -
Qualitative comparison of Malaysian and UK paracetamol tablets by Near-Infra Red
Said, M. M.; Gibbons, S.; Zloh, Mire (2009-09) -
Quantum chemical studies on structure activity relationship of natural product polyacetylenes
Zloh, Mire; Bucar, F.; Gibbons, S. (2007-02)An extract of the roots of Levisticum officinale L. (Apiaceae) exhibited significant antimycobacterial activity against Mycobacterium fortuitum, where diacetylene compounds were identified as the active components in this ... -
The role of complex formation between inhibitors and substrates of efflux pumps in bacteria
Rahman, S.S.; Chary, K.; Antoun, M.; Gibbons, S.; Zloh, Mire (2009-09) -
The role of small molecule-small molecule interactions in overcoming biological barriers for antibacterial drug action
Zloh, Mire; Gibbons, S. (2007-02)The ineffectiveness of antibiotics against bacteria can be caused by multidrug resistance (MDR) or by an outer membrane, which restricts the penetration of amphipathic compounds into Gram-negative bacteria. Remarkable ...