Browsing Research publications by Author "Kirton, Stewart"
Now showing items 1-17 of 17
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Anthracene based compounds and their uses
School of Life and Medical Sciences; Natural Product Chemistry and Drug Design; Centre for Research into Topical Drug Delivery and Toxicology; Psychopharmacology, Drug Misuse and Novel Psychoactive Substances Unit; Centre for Health Services and Clinical Research; Centre for Research in Mechanisms of Disease and Drug Discovery; Department of Clinical, Pharmaceutical and Biological Science; Rossiter, Sharon; Kirton, Stewart; Camara, Ramatoulie (2016-11-17) -
The benefits of in silico modeling to identify possible small-molecule drugs and their off-target interactions
Zloh, Mire; Kirton, Stewart (2018-02-01)The research into the use of small molecules as drugs continues to be a key driver in the development of molecular databases, computer-aided drug design software and collaborative platforms. The evolution of computational ... -
A Design-of-Experiments Approach to Developing Thermoresponsive Gelators From Complex Polymer Mixtures
Kirton, Stewart; Stair, Jacqueline; Abou Shamat, Mohamad; Calvo-Castro, Jesus; Cook, Michael T. (2020-10-13)This study investigated the effects of additives on the properties of poloxamer (P) 407 thermogels, employing a design-of-experiments (DoE) approach. P407 is a thermoresponsive triblock copolymer that exhibits a solution ... -
Detection of Newly Emerging Psychoactive Substances Using Raman Spectroscopy and Chemometrics
Calvo-Castro, Jesus; Guirguis, Amira; Samaras, Eleftherios; Zloh, Mire; Kirton, Stewart; Stair, Jacqueline (2018-09-12)A novel approach for the identification of New Psychoactive Substances (NPS) by means of Raman spectroscopy coupled with Principal Components Analysis (PCA) employing the largest dataset of NPS reference materials to date ... -
Discovery of novel small molecule inhibitors of S100P, with in vitro anti-metastatic effects on pancreatic cancer cells
Camara, Ramatoulie; Ogbeni, Deborah; Gerstmann, Lisa; Ostovar, Mehrnoosh; Hurer, Ellie; Scott, Mark; Mahmoud, Nasir; Radon, Tomasz; Crnogorac-Jurcevic, Tatjana; Patel, Pryank; Mackenzie, Louise Susan; Chau, David; Kirton, Stewart; Rossiter, Sharon (2020-10-01)S100P, a calcium- binding protein, is known to advance tumor progression and metastasis in pancreatic and several other cancers. Herein is described the in silico identification of a putative binding pocket of S100P to ... -
Drowning in Diversity? A systematic way of clustering a representative set of new psychoactive substances
Zloh, Mire; Samaras, Eleftherios; Calvo-Castro, Jesus; Guirguis, Amira; Stair, Jacqueline; Kirton, Stewart (2017-11-17)New psychoactive substances (NPS) can be generally described as a set of compounds that have been designed to mimic the effects of illegal recreational drugs, but are not subject to restriction or control with respect to ... -
Establishing the importance of oil-membrane interactions on the transmembrane diffusion of physicochemically diverse compounds
Najib, Omaima N.; Martin, Gary P; Kirton, Stewart; Sallam, Al-Sayed; Murnane, Darragh (2016-06-15)The diffusion process through a non-porous barrier membrane depends on the properties of the drug, vehicle and membrane. The aim of the current study was to investigate whether a series of oily vehicles might have the ... -
Identification of new psychoactive substances using Raman spectroscopy: handheld and computational approaches.
Guirguis, Amira; Kirton, Stewart; Zloh, Mire; Samaras, Eleftherios; Girotto, Sarah; Berti, Benedetta; Stair, Jacqueline (Research and Advances in Psychiatry, 2016-05)At this conference, I gave a presentation on the identification of new psychoactive substances using handheld Raman spectroscopy and chemometrics. -
In Silico Investigations into the Selectivity of Psychoactive and New Psychoactive Substances in Monoamine Transporters
Kirton, Stewart; Botha, Michelle (2022-11-01)New psychoactive substances (NPS) are a group of compounds that mimic the effects of illicit substances. A range of NPS have been shown to interact with the three main classes of monoamine transporters (DAT, NET, and SERT) ... -
Intended and Unintended Use of Cathinone Mixtures
Guirguis, Amira; Corkery, John; Stair, Jacqueline; Kirton, Stewart; Zloh, Mire; Schifano, Fabrizio (2017-06-28)Introduction: Cathinones are one of the most popular categories of new psychoactive substances (NPS) consumed. Cathinones have different pharmacological activities and receptor selectivity for monoamine transporters based ... -
New inhibitor targeting human transcription factor HSF1: effects on the heat shock response and tumour cell survival.
Kirton, Stewart (2017-03-21)Comparative modeling of the DNA-binding domain of human HSF1 facilitated the prediction of possible binding pockets for small molecules and definition of corresponding pharmacophores. In silico screening of a large library ... -
NPS detection in Prison: a Systematic Literature Review of Use, Drug Form, and Analytical Approaches
Stair, Jacqueline; Vaccaro, Giorgia; Guirguis, Amira; Kirton, Stewart; Massariol, Anna (2022-03-30)This paper presents a systematic literature review on the detection of new psychoactive substances (NPS) in prison settings. It includes the most frequently reported NPS classes, the routes and forms used for smuggling, ... -
Optimising poly(lactic-co-glycolic acid) microparticle fabrication using a Taguchi orthogonal array design-of-experiment approach
Mensah, Rosemond; Kirton, Stewart; Cook, Michael T.; Styliari, Ioanna Danai; Hutter, Victoria; Chau, David (2019-09-26)The objective of this study was to identify, understand and generate a Taguchi orthogonal array model for the formation of 10–50 μm microparticles with applications in topical/ocular controlled drug delivery. Poly(lactic ... -
Poly(N-isopropyl acrylamide) – poly(ethylene glycol) – poly(N-isopropyl acrylamide) as a thermoreversible gelator for topical administration
Haddow, Peter; McAuley, William; Kirton, Stewart; Cook, Michael T. (2020-05-06)Poly(N-isopropyl acrylamide) – block– poly(ethylene glycol) – block– poly(N-isopropyl acrylamide) is known to exhibit a thermally-induced solution-to-gel transition in water, which may be exploited for biomedical applications. ... -
Polymers exhibiting lower critical solution temperatures as a route to thermoreversible gelators for healthcare
Cook, Michael T.; Haddow, Peter; Kirton, Stewart; McAuley, William (2020-11-20)The ability to trigger changes to material properties with external stimuli, so-called “smart” behavior, has enabled novel technologies for a wide range of healthcare applications. Response to small changes in temperature ... -
Strategic Engagement: Exploring student buy-in across a formative and summative online assessment
Fergus, Suzanne; Hirani, Ektaa; Parkar, Nawal; Kirton, Stewart (2021-02-28)Assessment greatly influences the approaches students take in their learning. The nature of the assessment task, its educational value, outcomes and perceived importance can influence student engagement. PeerWise, a freely ... -
Survey of knowledge of legal highs (novel psychoactive substances) amongst London pharmacists
Guirguis, Amira; Corkery, John; Stair, Jacqueline; Kirton, Stewart; Zloh, Mire; Goodair, Christine; Schifano, Fabrizio; Davidson, Colin (2015-06-01)Purpose: To determine pharmacists’ knowledge of legal highs (novel psychoactive substances; NPS). Approach: A questionnaire was handed out at 2 London pharmacist continuing education events in mid-2014. These events update ...