Browsing Research publications by Author "Murdock, P."
Now showing items 1-4 of 4
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Characterization of the human HCN1 subunit and its inhibition by capsazepine
Gill, C.H.; Bates, S.A.; Owen, D.; Larkman, P.; Cairns, W.; Yusuf, S.; Murdock, P.; Strijbos, P.; Powell, A.; Benham, C.D.; Davies, C.H. (2004)The human hyperpolarization-activated cyclic nucleotide-gated 1 (hHCN1) subunit was heterologously expressed in mammalian cell lines (CV-1 and CHO) and its properties investigated using whole-cell patch-clamp recordings. ... -
Cloning and functional expression of a human orthologue of the rat vanilloid receptor-1
Hayes, P.; Meadows, H.J.; Gunthorpe, M.J.; Harries, M.; Duckworth, M.; Cairns, W.; Harrison, D. C.; Ellington, K.; Prinjha, R.; Barton, A.; Medhurst, A.D.; Smith, G.D.; Topp, S.; Sanger, G.; Jenkins, O.; Benham, C.D.; Gloger, I.; Clarke, C. E.; Murdock, P.; Terrett, J.; Randall, A. D.; Gloger, I. S.; Davis, J. B. (2000-11-01)Capsaicin, resiniferatoxin, protons or heat have been shown to activate an ion channel, termed the rat vanilloid receptor-1 (rVR1), originally isolated by expression cloning for a capsaicin sensitive phenotype. Here we ... -
Cloning, localisation and functional expression of the human ortholgue of the TREK-1 potassium channel
Meadows, H.J.; Benham, C.D.; Cairns, W.; Gloger, I.; Jennings, C.; Medhurst, A.D.; Murdock, P.; Chapman, C.G. (2000)We have cloned human TREK-1, one of the newly emerging mammalian family of 2-P domain potassium channels. The channel has 411 amino acids with a 41-amino-acid extension at the C-terminus when compared with the cloned mouse ... -
Tissue distribution profiles of the human TRPM cation channel family
Fonfria, E.; Murdock, P.; Cusdin, F.S.; Benham, C.D.; Kelsell, R.E.; McNulty, S. (2006)