Now showing items 1-5 of 5
Rationalising polymer selection for supersaturated film forming systems produced by an aerosol spray for the transdermal delivery of methylphenidate
Film forming systems offer a number of advantages for topical and transdermal drug delivery, in particular enabling production of a supersaturated state which can greatly improve drug absorption and bioavailability. However ...
Disc-shaped polyoxyethylene glycol glycerides gel nanoparticles as novel protein delivery vehicles
Disc-shaped nanoparticles with high aspect ratios have been reported to show preferential cellular uptake in vitro by mammalian cells. However, engineering and producing such disc-shaped nanoparticles are often complex. ...
Physical stabilization of low-molecular-weight amorphous drugs in the solid state : a material science approach
Use of the amorphous state is considered to be one of the most effective approaches for improving the dissolution and subsequent oral bioavailability of poorly water-soluble drugs. However as the amorphous state has much ...
Stabilisation of amorphous drugs under high humidity using pharmaceutical thin films
In this study, the stabilization effects of three polymers on four model drugs (felodipine, fenofibrate, carbamazepine, and celecoxib) under saturated humidity were investigated. Three different types of thin films (solid ...
Moisture uptake of polyoxyethylene glycol glycerides used as matrices for drug delivery : kinetic modelling and practical implications
Gelucire 50/13, a polyoxyethylene glycol glyceride mixture, has been widely used in drug delivery, but its moisture uptake behaviour is still poorly understood. In this study, the effects of relative humidity, temperature, ...