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A New Pyridazine Series of GABAA α5 Ligands
(2005-09-22)
Screening of the Merck compound collection identified 6 as an unusually simple, low molecular weight hit with moderate affinity for GABAA receptors. The structural novelty of 6, compared to our advanced series of GABAA α5 ...
The effect of unsaturated fatty acids in benzyl alcohol on the percutaneous permeation of three model penetrants
(2005-09-14)
The model penetrants butyl paraben (BP), methyl paraben (MP) and caffeine (CF), because of their different octanol/water partition coefficients and postulated routes of permeation through human skin, were selected to assess ...
Agricultural Advisory Services Content Audit
(Department for Environment, Food and Rural Affairs (Defra), 2005-09-08)
Raman lidar observations of aged Siberian and Canadian forest fire smoke in the free troposphere over Germany in 2003 : Microphysical particle characterization
(2005-09-02)
Dual-wavelength Raman lidar observations were regularly carried out at Leipzig (51.3 degrees N, 12.4 degrees E) from May to August 2003. The measurements showed that particle backscatter and extinction coefficients in the ...
Comparison of the efficacy of ramoplanin and vancomycin in both in vitro and in vivo models of clindamycin-induced Clostridium difficile infection
(2005-09)
Treatment of Clostridium difficile infection (CDI) is limited primarily to either metronidazole or vancomycin. We compared vancomycin and a novel glycolipodepsipeptide, ramoplanin, in both hamster and in vitro gut models ...
Unilateral pallidotomy in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated common marmosets exhibiting levodopa-induced dyskinesia
(2005-09)
Pallidotomy paradoxically reduces the intensity of levodopa-induced dyskinesia without worsening motor symptoms. The reasons for this are not clear and no experimental study has investigated this phenomenon. The objective ...
On the globular cluster formation history of NGC 5128
(2005-09-01)
We deduce the globular cluster formation history of the nearby elliptical galaxy, NGC 5128, by using a chemical enrichment model to accurately reproduce its observed metallicity distribution function (MDF). We derive the ...
Design Research in Brazil
(Design Research Society, 2005-09)