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Evaluation of transabdominal and transperineal ultrasound-derived prostate specific antigen (PSA) density and clinical utility compared to MRI prostate volumes: A feasibility study
(2022-09-09)
Purpose: To investigate the accuracy of surface-based ultrasound-derived PSA-density (US-PSAD) versus gold-standard MRI-PSAD as a risk-stratification tool. Methods: Single-centre prospective study of patients undergoing ...
Parenclitic and Synolytic Networks Revisited
(2021-10-20)
Parenclitic networks provide a powerful and relatively new way to coerce multidimensional data into a graph form, enabling the application of graph theory to evaluate features. Different algorithms have been published for ...
Implementation of Multigene Germline and Parallel Somatic Genetic Testing in Epithelial Ovarian Cancer: SIGNPOST Study
(2021-08-27)
We present findings of a cancer multidisciplinary-team (MDT) coordinated mainstreaming pathway of unselected 5-panel germline BRCA1/BRCA2/RAD51C/RAD51D/BRIP1 and parallel somatic BRCA1/BRCA2 testing in all women with ...
Comparative performance of MRI-derived PRECISE scores and delta-radiomics models for the prediction of prostate cancer progression in patients on active surveillance
(2021-07-13)
Objectives: To compare the performance of the PRECISE scoring system against several MRI-derived delta-radiomics models for predicting histopathological prostate cancer (PCa) progression in patients on active surveillance ...
Risk factors for long covid in previously hospitalised children using the ISARIC Global follow-up protocol: A prospective cohort study : A prospective cohort study
(2021-07-01)
BACKGROUND: The long-term sequelae of coronavirus disease 2019 (Covid-19) in children remain poorly characterised. This study aimed to assess long-term outcomes in children previously hospitalised with Covid-19 and associated ...
MRI-derived radiomics model for baseline prediction of prostate cancer progression on active surveillance
(2021-06-21)
Nearly half of patients with prostate cancer (PCa) harbour low- or intermediate-risk disease considered suitable for active surveillance (AS). However, up to 44% of patients discontinue AS within the first five years, ...
A time-resolved proteomic and prognostic map of COVID-19
(2021-06-14)
COVID-19 is highly variable in its clinical presentation, ranging from asymptomatic infection to severe organ damage and death. We characterized the time-dependent progression of the disease in 139 COVID-19 inpatients by ...
Media Influence on Anxiety, Health Utility, and Health Beliefs Early in the SARS-CoV-2 Pandemic-a Survey Study
(2021-02-24)
Background: The psychological effects from the COVID-19 pandemic and response are poorly understood. Objective: To understand the effects of the pandemic and response on anxiety and health utility in a nationally representative ...
Non-Histone Protein Methylation: Biological Significance and Bioengineering Potential
(2021-02-19)
Protein methylation is a key post-translational modification whose effects on gene expression have been intensively studied over the last two decades. Recently, renewed interest in non-histone protein methylation has gained ...