Research publications: Recent submissions
Now showing items 1341-1360 of 9764
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A Structural Investigation of the Epstein—Barr (EB) Virus Membrane Antigen Glycoprotein, gp340
(1984-02)Epstein—Barr (EB) virus membrane antigen (MA) glycoprotein (gp340) purified by a molecular weight-based technique has been subjected to biochemical analysis. Following treatment with glycosidases or tunicamycin during ... -
Electron-rich heteroaroylphosphonates and their reaction with trimethyl phosphite
(2008)Dialkyl heteroaroylphosphonates based on thiophene, pyrrole or furan have been prepared and their reactions with trimethyl phosphite investigated. Deoxygenation of the carbonyl groups in these heteroaroylphosphonates occurs ... -
A novel approach to isoindolo[2,1-a]indol-6-ones
(2012)A convenient route to isoindolo[2,1-a]indol-6-ones has been developed starting from the appropriate 2-(N-phthaloyl)benzoic acids. Formation of the acid chlorides with thionyl chloride followed by heating with triethyl ... -
Novel Ylidic Phosphoryl Compounds from Halogenated Furan-2,5-Diones with Trivalent Phosphorus Esters: Application of this Approach to New Trisphosphonates Containing a Geminal Bisphosphonate Unit
(2014-08-03)The reactions of trivalent phosphorus esters, including trialkyl phosphites, dialkyl phosphonites, and alkyl phosphinites, with 3-halo- and 3,4-dihalo-furan-2,5-diones has been shown to lead to the formation of novel ... -
Studies of the reactions of tripodal pyridine-containing ligands with Re(CO)5Br leading to rheniumtricarbonyl complexes with potential biomedical applications
(2011)The complexes formed from the reaction of N-acylated tris-(pyridin-2-yl)methylamine (LH) with [Re(CO)5Br] depend on the structure of the ligand and the reaction conditions. Thus, while N-[1,1,1-tris-(pyridin-2-yl)methyl]acetamide ... -
Studies of rheniumtricarbonyl complexes of tripodal pyridyl-based ligands
(2010-04-05)The reaction of N-benzoyl and N-acetyl tris(pyridin-2-yl)methylamine 1b and 1c (LH = tpmbaH and tpmaaH) with [Re(CO)5Br] has been investigated and shown to proceed via the initial formation of a cationic rheniumtricarbonyl ... -
Cyclisation reactions of 2-substituted benzoylphosphonates with trialkyl phosphites via nucleophilic attack on a carbonyl-containing ortho substituent
(2008-03-03)Dimethyl 2-acetoxy- and dimethyl 2-benzoyloxy-benzoylphosphonate undergo cyclisation and deoxygenation in the presence of excess trimethyl phosphite to give dimethyl (3-methyl-1-benzofuran-2-yl)phosphonate and dimethyl ... -
The impact of process parameters on mechanical properties of parts fabricated in PLA with an open-source 3-D printer
(2015-08-17)Purpose - This study aims to quantify the ultimate tensile strength and the nominal strain at break (f) of printed parts made from polylactic acid (PLA) with a Replicating Rapid prototyper (Rep-Rap) 3D printer, by varying ... -
Solution structure of the inner DysF domain of myoferlin and implications for limb girdle muscular dystrophy type 2b
(2008-06-20)Mutations in the protein dysferlin, a member of the ferlin family, lead to limb girdle muscular dystrophy type 2B and Myoshi myopathy. The ferlins are large proteins characterised by multiple C2 domains and a single ... -
The new CCP4 Coordinate Library as a toolkit for the design of coordinate-related applications in protein crystallography
(2004-12)The new CCP4 Coordinate Library is a development aiming to provide a common layer of coordinate-related functionality to the existing applications in the CCP4 suite, as well as a variety of tools that can simplify the ... -
Ongoing developments in CCP4 for high-throughput structure determination
(2002-11)Collaborative Computational Project Number 4 (CCP4) was established in 1979 to promote collaboration between UK groups writing software for protein crystallography. From these beginnings, CCP4 now distributes a large ... -
Metastasis-promoting anterior gradient 2 protein has a dimeric thioredoxin fold structure and a role in cell adhesion
(2013-03-11)Anterior gradient 2 (AGR2) is a normal endoplasmic reticulum protein that has two important abnormal functions, amphibian limb regeneration and human cancer metastasis promotion. These normal intracellular and abnormal ... -
Who Was William Shakespeare?
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Dealing with self-interest among non-executive directors
(2015-05)No director should operate from self-interest whether executive or non-executive. Here, David Gibbs, Lecturer in Company and Commercial Law at the University of Hertfordshire School of Law in the United Kingdom, uses the ... -
Frozen shoulder contracture syndrome - Aetiology, diagnosis and management
(2015-02)Frozen shoulder is a poorly understood condition that typically involves substantial pain, movement restriction, and considerable morbidity. Although function improves overtime, full and pain free range, may not be restored ... -
Agreement among optometrists and ophthalmologists in estimating limbal anterior chamber depth using the van Herick method
(2015-03)Purpose: To evaluate the inter-observer agreement for measuring limbal anterior chamber depth (LACD) using the van Herick test in community optometrists, glaucoma specialist optometrists and ophthalmologists. Methods: The ... -
The complexity of enforcing intellectual property rights in the absence of antitrust legislation and a related enforcement institution : a classic policy failure in Ghana
(2013)Owing to the fact that TRIPS provides for a stringent enforcement of IPRs, this article examines the consequences of enforcing IPRs in the absence of an antitrust legislation and a related enforcement institution in Ghana. ...