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Browsing by Author "Murnane, Darragh"
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The influence of oily vehicle composition and vehicle-membrane interactions on the diffusion of model permeants across barrier membranes
Najib, Omaima N.; Martin, Gary P.; Kirton, Stewart B.; Botha, Michelle J.; Sallam, Al Sayed; Murnane, Darragh (2021-01-14)In many instances, one or more components of a pharmaceutical or cosmetic formulation is an oil. The aims of this study were two-fold. First, to examine the potential of preferential uptake of one oily vehicle component ... -
Interaction of Formulation and Device Factors Determine the In Vitro Performance of Salbutamol Sulphate Dry Powders for Inhalation
Muddle, Joanna; Murnane, Darragh; Parisini, Irene; Brown, Marc; Page, Clive; Forbes, Ben (2015-11-01)A variety of capsule-based dry powder inhalers were used to evaluate formulation-device interaction. The in vitro deposition of salbutamol sulphate (SS) was compared directly to published data for salmeterol xinafoate (SX). ... -
Intranasal Vaccine Formulation: Advancing Towards Nasal Dry Powder Formulation
Forkuoh, Kelvin; Urbano, Laura; Kerai-Varsani, Laxmi; Murnane, Darragh (2023-12-31)Unlike conventional mRNA vaccines, intranasal vaccines display several advantages, including the ability to generate strong mucosal immunity. However, the formulation challenges associated with intranasal mRNA vaccines ... -
Investigating the suitability of high content image analysis as a tool to assess the reversibility of foamy alveolar macrophage phenotypes in vitro.
Hoffman, Ewelina; Murnane, Darragh; Hutter, Victoria (2020-03-13)Many potential inhaled medicines fail during development due to the induction of a highly vacuolated or “foamy” alveolar macrophage phenotype response in pre-clinical studies. There is limited understanding if this response ... -
Investigations into the formulation of metered dose inhalers of salmeterol xinafoate and fluticasone propionate microcrystals
Murnane, Darragh; Martin, Gary P.; Marriott, Christopher (2008-10)Purpose. To investigate the aerosolization and behaviour of microparticles of salmeterol xinafoate (SX) and fluticasone propionate (FP) suspended in hydrofluoroalkane (HFA) propellant. Methods. Microcrystals of SX and FP ... -
Mathematical approach for understanding deagglomeration behaviour of drug powder in formulations with coarse carrier
Parisini, Irene; Collett, James L.; Murnane, Darragh (2015-12-01)Deagglomeration of cohesive particles in combination with coarse carrier is a key requirement for inhaled formulations. The aim of the project was to propose a mathematical approach to understand aerosolization behaviour ... -
Microstructural insight into inhalation powder blends through correlative multi-scale X-ray Computed Tomography
Gajjar, Parmesh; Styliari, Ioanna Danai; Legh-Land, Victoria; Bale, Hrishikesh; Tordoff, Benjamin; Withers, Philip; Murnane, Darragh (2023-10-30)Dry powder inhalers (DPI) are important for topical drug delivery to the lungs, but characterising the pre-aerosolised powder microstructure is a key initial step in understanding the post-aerosolised blend performance. ... -
Molecular Synthon Modelling Of Inhalation Pharmaceuticals: A Digital Approach To Understanding And Engineering Particle Surface Interactions
Nguyen, Thai T. H.; Hammond, Robert; Styliari, Ioanna Danai; Murnane, Darragh; Roberts, Kevin J. (2020-02-19) -
Multiscale Tomography: Probing The Nano-, Micro-, And Meso-Scale Resolution Of Inhalation Powder Structure
Gajjar, Parmesh; Styliari, Ioanna Danai; Burnett, Timothy; Chen, Xizhong; Elliot, James A.; Ganley, William J.; Hammond, Robbert; Nguyen, Hien; Price, Robert; Roberts, Kevin; Withers, Philip; Murnane, Darragh (Respiratory Drug Delivery, RDD, 2019-05-07)Understanding the agglomeration behavior of inhaled formulations is essential to ensure consistent aerosolization performance that maximizes drug deposition in the lower respiratory tract. Although many techniques are ... -
Multivariate analytical approaches to identify key molecular properties of vehicles, permeants and membranes that affect permeation through membranes
Najib, Omaima N.; Kirton, Stewart B.; Martin, Gary P.; Botha, Michelle J.; Sallam, Al Sayed; Murnane, Darragh (2020-10-31)There has been considerable recent interest in employing computer models to investigate the relationship between the structure of a molecule and its dermal penetration. Molecular permeation across the epidermis has previously ... -
Nitrogen-14 Nuclear Quadrupole Resonance Spectroscopy: : a powerful new analytical methodology for medicines authentication and counterfeit antimalarial analysis
Barras, Jamie; Murnane, Darragh; Althoefer, Kaspar; Assi, Sulaf; Rowe, MIchael D.; Poplett, Iain J. F.; Kyriakidou, Georgia; Smith, John A. S. (2013-02-05)We report the detection and analysis of a suspected counterfeit sample of the antimalarial medicine Metakelfin through developing Nitrogen-14 Nuclear Quadrupole Resonance (14N NQR) spectroscopy at a quantitative level. The ... -
On Measuring the Specific Surface Area of inhalation-grade lactose powders
Styliari, Ioanna Danai; Nguyen, Thai TH; Gajjar, Parmesh; Tordoff, Benjamin; Burnett, Timothy; Withers, Philip; Hammond, Robert B.; Roberts, Kevin J.; Murnane, Darragh (2020-01-28) -
Optimizing the Entrainment Geometry of a Dry Powder Inhaler : Methodology and Preliminary Results
Kopsch, Thomas; Murnane, Darragh; Symons, Digby (2016-11-01)Purpose: For passive dry powder inhalers (DPIs) entrainment and emission of the aerosolized drug dose depends strongly on device geometry and the patient’s inhalation manoeuvre. We propose a computational method for ... -
A personalized medicine approach to the design of dry powder inhalers: : Selecting the optimal amount of bypass
Kopsch, Thomas; Murnane, Darragh; Symons, Digby (2017-08-30)In dry powder inhalers (DPIs) the patient's inhalation manoeuvre strongly influences the release of drug. Drug release from a DPI may also be influenced by the size of any air bypass incorporated in the device. If the ... -
Physicochemical characterisation of inhalation grade lactose after the removal of intrinsic fines
Styliari, Ioanna Danai; Mobli, Arian; Murnane, Darragh (2018-12-14)Lactose is a common excipient in Dry Powder Inhaler (DPI) formulations, used as a carrier for the micronized drug particles. The presence of intrinsic lactose fines in the formulation influences its performance and their ... -
Polymer architecture dictates thermoreversible gelation in engineered emulsions stabilised with branched copolymer surfactants
Rajbanshi, Abhishek; Alves da Silva, Marcelo; Murnane, Darragh; Porcar, Lionel; Dreiss, Cécile A.; Cook, Michael T. (2022-09-26)The generation of materials that switch from a liquid to gel state upon warming can enable new healthcare technologies with improved functionality, such as in situ gel-forming materials for drug delivery to topical or ... -
Polymorphic control of inhalation microparticles prepared by crystallization
Murnane, Darragh; Marriott, Christopher; Martin, Gary P. (2008-09-01)Milling processes are known to cause polymorphic transition in enantiotropic systems and the micronization process employed to produce microparticles for inhalation formulations has been reported to result in solid-state ... -
Potential of a cyclone prototype spacer to improve in vitro dry powder delivery
Parisini, Irene; Cheng, Sean J; Symons, Digby; Murnane, Darragh (2014-05)Purpose: Low inspiratory force in patients with lung disease is associated with poor deagglomeration and high throat deposition when using dry powder inhalers (DPIs). The potential of two reverse flow cyclone prototypes ... -
Predicting the Fine Particle Fraction of Dry Powder Inhalers Using Artificial Neural Networks
Muddle, Joanna; Kirton, Stewart B.; Parisini, Irene; Muddle, Andrew; Murnane, Darragh; Ali, Jogoth; Brown, Marc; Page, Clive; Forbes, Ben (2017-01-01)Dry powder inhalers are increasingly popular for delivering drugs to the lungs for the treatment of respiratory diseases, but are complex products with multivariate performance determinants. Heuristic product development ... -
Predicting the Strength of Cohesive and Adhesive Interparticle Interactions for Dry Powder Inhalation Blends of Terbutaline Sulfate with α‑Lactose Monohydrate
Ma, Cai Y.; Nguyen, Thai T. H.; Gajjar, Parmesh; Styliari, Ioanna D.; Hammond, Robert B.; Withers, Philip J.; Murnane, Darragh; Roberts, Kevin J. (2023-09-08)Grid-based systematic search methods are used to investigate molecule–molecule, molecule–surface, and surface–surface contributions to interparticle interactions in order to identify the crystal faces that most strongly ...