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Browsing by Author "Centre for Research in Mechanisms of Disease and Drug Discovery"
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Neuropeptide Y in rat detrusor and its effect on nerve-mediated and acetylcholine-evoked contractions
Iravani, Mahmoud M.; Zar, M. A. (1994-09)1 Immunohistochemical and isolated organ bath techniques were used to detect the presence of neuropeptide Y (NPY) in the rat urinary bladder and to determine its effect on tone, spontaneous activity and contractile responses ... -
The neuroprotective properties of NLX-112 in MPTP treated mice are mediated by reactive gliosis and astrocytic GDNF
Powell, William; Depoortere, Ronan; Annett, Lucy; Newman-Tancredi, Adrian; Iravani, Mahmoud (SAGE Publications, 2023-05-30)Introduction: Preventing dopaminergic (DA) neuronal death is key to halting the progression of Parkinson’s Disease (PD). There is evidence for serotonin 5-HT1A agonists having neuroprotective effects on DA neurons. NLX-112 ... -
The new CCP4 Coordinate Library as a toolkit for the design of coordinate-related applications in protein crystallography
Krissinel, E.B.; Winn, M.D.; Ballard, C.C.; Ashton, A.W.; Patel, Pryank; Potterton, E.A.; McNicholas, S.J.; Cowtan, K.D.; Emsley, P. (2004-12)The new CCP4 Coordinate Library is a development aiming to provide a common layer of coordinate-related functionality to the existing applications in the CCP4 suite, as well as a variety of tools that can simplify the ... -
New inhibitor targeting human transcription factor HSF1: effects on the heat shock response and tumour cell survival.
Kirton, Stewart (2017-03-21)Comparative modeling of the DNA-binding domain of human HSF1 facilitated the prediction of possible binding pockets for small molecules and definition of corresponding pharmacophores. In silico screening of a large library ... -
New trends of drug abuse in custodial settings: a systematic review on the misuse of over-the-counter drugs, prescription-only-medications, and new psychoactive substances
Chiappini, Stefania; Vaccaro, Giorgia; Mosca, Alessio; Miuli, Andrea; Stigliano, Gianfranco; Stefanelli, Giulia; Giovannetti, Giulia; Carullo, Rosalba; d'Andrea, Giacomo; Di Carlo, Francesco; Cavallotto, Clara; Pettorruso, Mauro; Di Petta, Gilberto; Corkery, John Martin; Guirguis, Amira; Stair, Jacqueline L.; Martinotti, Giovanni; Fazel, Seena; Schifano, Fabrizio (2024-07-30)The article presents a systematic literature review on the use and the psychiatric implications of over-the-counter drugs (OTC), prescription-only-medications (POM), and new psychoactive substances (NPS) within custodial ... -
Nitazoxanide is active against Clostridium difficile strains with reduced susceptibility to metronidazole
Freeman, Jane; Baines, Simon D.; Todhunter, Sharie L.; Huscroft, Grace S.; Wilcox, M. H. (2011)Treatment strategies for Clostridium difficile infection (CDI) have changed little over the past two decades. Metronidazole and vancomycin continue to be the first-line antimicrobial treatments for CDI.1 While the drugs ... -
NMDA releases a nitric oxide-like substance in rat striatum : a study using fast cyclic voltammetry
Iravani, Mahmoud M.; Millar, J.; Kruk, Z. L. (1994-07) -
The non-genomic effects of the PPARβγ agonist GW0742 on streptozotocin treated rat aorta
Perez-Diaz, Noelia; Pushkarsky, Igor; Oweis, Nadia; Lione, Lisa; Mackenzie, Louise S (2018-05-01)Background: The ubiquitous nuclear receptor PPARβ/δ is increasingly being studied in regards to numerous diseases including diabetes following on the finding that PPARβ/δ agonist GW0742 controls Type 1 Diabetes in rats. ... -
Non-Toxigenic Clostridioides difficile Strain E4 (NTCD-E4) Prevents Establishment of Primary C. difficile Infection by Epidemic PCR Ribotype 027 in an In Vitro Human Gut Model
Etifa, Perezimor; Rodríguez, César; Harmanus, Céline; Sanders, Ingrid M. J. G.; Sidorov, Igor A.; Mohammed, Olufunmilayo A.; Savage, Emily; Timms, Andrew R.; Freeman, Jane; Smits, Wiep Klaas; Wilcox, Mark H.; Baines, Simon D. (2023-02-22)Clostridioides difficile infection (CDI) remains a significant healthcare burden. Non-toxigenic C. difficile (NTCD) strains have shown a benefit in preventing porcine enteritis and in human recurrent CDI. In this study, ... -
Noradrenergic mechanisms in the prefrontal cortex.
Nutt, D.J.; Lalies, M.D.; Lione, Lisa; Hudson, A.L. (1997)There is growing evidence that noradrenergic inputs to the prefrontal cortex (PFC) play an important role in regulating its function. This paper reviews the pharmacological control of noradrenaline (NA) release in this ... -
A Novel Epigenetic Strategy to Concurrently Block Immune Checkpoints PD-1/PD-L1 and CD155/TIGIT in Hepatocellular Carcinoma
Assal, Reem A.; Elemam, Noha M.; Mekky, Radwa Y.; Attia, Abdelrahman A.; Soliman, Aya Hesham; Gomaa, Asmaa Ibrahim; Efthimiadou, Eleni K.; Braoudaki, Maria; Fahmy, Sherif Ashraf; Youness, Rana A. (2024-04-17)Tumor microenvironment is an intricate web of stromal and immune cells creating an immune suppressive cordon around the tumor. In hepatocellular carcinoma (HCC), Tumor microenvironment is a formidable barrier towards novel ... -
The Novel Phages phiCD5763 and phiCD2955 Represent Two Groups of Big Plasmidial Siphoviridae Phages of Clostridium difficile
Ramírez-Vargas, Gabriel; Goh, Shan; Rodríguez, César (2018-01-22)Until recently, Clostridium difficile phages were limited to Myoviruses and Siphoviruses of medium genome length (32–57 kb). Here we report the finding of phiCD5763, a Siphovirus with a large extrachromosomal circular ... -
Novel Psychoactive Substance (NPS) awareness, use and health perception following The UK Psychoactive Substances Act 2016
Deligianni, Elena; Daniel, Omari-Jordan; Corkery, John; Schifano, Fabrizio; Lione, Lisa (2017-10-23)Introduction: The risk of potential harms prompted the UK government to introduce The Psychoactive Substances Act (PSA) in 2016 banning the production, supply, importation and exportation of NPS 1. Here we investigate UK ... -
Novel psychoactive substances (NPS) – knowledge and experiences of drug users from Hungary, Poland, the UK and the USA
Pisarska, Agnieszka; Deluca, Paolo; Demetrovics, Zsolt; Corkery, John; Moskalewicz, Jacek; ReDNet Group; Corazza, Ornella; Corkery, John; Stair, Jacqueline; Fergus, Suzanne; Pezzolesi, Cinzia; Schifano, Fabrizio (2020-02-18)Dopamine D 3 receptor partial agonists represent a new generation of atypical antipsychotics. Cariprazine, which has received centralized market authorization from the European Medicines Agency in 2017 for the treatment ... -
Novel selective compounds for the investigation of imidazoline receptors
Hudson, A.L.; Gough, R.; Tyacke, Robin; Lione, Lisa; Lalies, M.D.; Lewis, J.; Husbands, S.; Knight, P.; Murray, F.; Hutson, P.; Nutt, D.J. (1999-06)Over several years our group has sought to synthesize and identify selective ligands for imidazoline (I) receptors, in particular the I2 binding site. As a consequence, [3H]2-(2-benzofuranyl)-2-imidazoline (2BFI) has proved ... -
Novel Siglec-15-Sia axis inhibitor leads to colorectal cancer cell death by targeting miR-6715b-3p and oncogenes
Ahmad, Mohammed Saqif; Braoudaki, Maria; Patel, Hershna; Ahmad, Irshad; Waseem, Shagufta; Siddiqui, Shoib (2023-10-06)Siglecs are well known immunotherapeutic targets in cancer. Current checkpoint inhibitors have exhibited limited efficacy, prompting a need for novel therapeutics for targets such as Siglec-15. Presently, small molecule ... -
Novel stem cell technologies are powerful tools to understand the impact of human factors on Plasmodium falciparum malaria
Pance, Alena; Ng, Bee Ling; Mwikali, Kioko; Koutsourakis, Manousos; Agu, Chukwuma; Rouhani, Foad J.; Montandon, Ruddy; Law, Frances; Ponstingl, Hannes; Rayner, Julian C. (2023-12-19)Plasmodium falciparum parasites have a complex life cycle, but the most clinically relevant stage of the disease is the invasion of erythrocytes and the proliferation of the parasite in the blood. The influence of human ... -
Novel systems to study vector-pathogen interactions in malaria
Parres-Mercader, Marina; Pance, Alena; Gómez-Díaz, Elena (2023-05-26)Some parasitic diseases, such as malaria, require two hosts to complete their lifecycle: a human and an insect vector. Although most malaria research has focused on parasite development in the human host, the life cycle ... -
De novo ligand design to partially flexible active sites : Application of the Reflex algorithm to carboxypeptidase A, acetylcholinesterase, and the estrogen receptor
Firth-Clark, Stuart; Kirton, Stewart B.; Willems, Henrite M. G.; Williams, Anthony (2008-02)Reflex is a recent algorithm in the de novo ligand design software, SkelGen, that allows the flexibility of amino acid side chains in a protein to be taken into account during the drug-design process. In this paper the ... -
Nowe substancje psychoaktywne : potrzeby informacyjne młodzieży I profesjonalistów
Pisarska, Agnieszka; Moskalewicz, Jacek; Corazza, Ornella; Assi, Sulaf; Simonato, Pierluigi; Corkery, John; Demetrovics, Zsolt; Stair, Jacqueline; Fergus, Suzanne; Pezzolesi, Cinzia; Pasinetti, Manuela; Deluca, Paolo; Drummond, Colin; Blaszko, Ursula; Mervo, Barbara; Di Furia, Lucia; Farre, Magi; Flesland, Liv; Shapiro, Harry; Siemann, Holger; Skutle, Arvid; Torrens, Marta; Sambola, Farran; van der Kreeft, Peer; Scherbaum, Norbert; Schifano, Fabrizio (2013-06)(translated from Polish) The study conducted in the frame of the RedNet project among health professionals dealing with drug users (N=124) and youth population (N=716) was aimed at assessment of the level of knowledge about ...