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Now showing items 17989-18008 of 24473
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Prostate cancer cells stimulated by calcium-mediated activation of protein kinase C undergo a refractory period before re-releasing calcium-bearing microvesicles
(2015-05-08)MVs are released in response to several stress agents, in an attempt to prevent continued cellular damage. After an initial stimulus of prostate cancer cells with sublytic C5b-9 and activation of MV release through PKC, ... -
Proteasomal abnormalities in cortical Lewy body disease and the impact of proteasomal inhibition within cortical and cholinergic systems
(2008-06)Dementia with Lewy bodies (DLB) accounts for 15-20% of the millions of people worldwide with dementia. In the current work we investigate the association between proteasome dysfunction and the development of cortical Lewy ... -
Protection Versus Pathology in Aviremic and High Viral Load HIV-2 Infection : The Pivotal Role of Immune Activation and T-cell Kinetics
(2014-09-01)BACKGROUND: Many human immunodeficiency virus (HIV)-2-infected individuals remain aviremic and behave as long-term non-progressors but some progress to AIDS. We hypothesized that immune activation and T-cell turnover would ... -
Protective mechanism of stabilising excipients against dehydration in the freeze-drying of proteins
(2002)To investigate the influence of type and amount of excipient on the preservation of the native structure and the biologic activity of freeze-dried lysozyme and catalase -
Protein binding and in vitro serum thromboxane B2 inhibition by flunixin meglumine and meclofenamic acid in dog, goat and horse blood
(1996-07)lunixin was highly protein bound in the serum of dogs (92.2 per cent), gents (84.8 per cent) and horses (86.9 per cent). Meclofenamic acid was also highly protein bound, although there were larger differences between the ... -
Protein droplet actuation on superhydrophobic surfaces: A new approach toward anti-biofouling electrowetting systems
(2017-10-25)Among Lab-on-a-chip techniques, Digital microfluidics (DMF), allowing the precise actuation of discrete droplets, is a highly promising, flexible, biochemical assay platform for biomedical and bio-detection applications. ... -
Proteinase K (EC 3.4.21.14)
(1993)Proteinase K is a serine protease and the main proteolytic enzyme produced by the fungus Tritirachium album Limber (l). The enzyme has a broad specificity, cleaving peptide bonds C-terminal to a number of amino acids. The ... -
Proteomic biomarkers of peripheral blood mononuclear cells obtained from postmenopausal women undergoing an intervention with soy isoflavones
(2007-11)The incidence of cardiovascular diseases increases after menopause, and soy consumption is suggested to inhibit disease development. -
A proteomic survival predictor for COVID-19 patients in intensive care
(2022-01-18)Global healthcare systems are challenged by the COVID-19 pandemic. There is a need to optimize allocation of treatment and resources in intensive care, as clinically established risk assessments such as SOFA and APACHE II ... -
Protest and the Politics of Space and Place, 1789-1848
(Manchester University Press, 2015-12-01)This book is a wide-ranging survey of the rise of mass movements for democracy and workers’ rights in northern England. It is a provocative narrative of the closing down of public space and dispossession from place. The ... -
Protest History or the History of Protest?
(2012-04-01)A workshop on ‘new approaches to the history of protest and collective action’ was held at the University of Hertfordshire on 1 July 2011. The event could not have been at a more opportune time. The day before the workshop, ... -
The Protestant Funeral Sermon in England, 1688-1800
(Oxford University Press (OUP), 2012)An overview of the development, popularity, and cultural importance of the published British Protestant funeral sermon from 1689 to 1800 -
Proto
(Screen South, 2012)‘PROTO’ is a sci-fi action adventure, about a child-like, experimental robot, set in the robotics lab where he has been built. Although PROTO has been made to fulfil the ambitions of his creator, Prof. Andrews, he learns ... -
Protocol for a mixed-methods exploratory investigation of care following intensive care discharge: the REFLECT study
(2019-01-25)INTRODUCTION: A substantial number of patients discharged from intensive care units (ICUs) subsequently die without leaving hospital. It is unclear how many of these deaths are preventable. Ward-based management following ... -
Protocol for a realist evaluation of Recovery College dementia courses: understanding coproduction through ethnography
(2023-12-07)Introduction: Support following a dementia diagnosis in the UK is variable. Attending a Recovery College course with and for people with dementia, their supporters and healthcare professionals (staff), may enable people ... -
Protocol for a realist review of General Practitioners’ Role in Advancing Practice in Care Homes (GRAPE study)
(2020-06-15)Introduction Older people who live in care homes have a high level of need with complex health conditions. In addition to providing medical care to residents, general practitioners (GPs) play a role as gatekeeper for access ... -
A protocol for a scoping review of the use of mental simulation and full-scale simulation in practising healthcare decision-making skills of undergraduate nursing students
(2023-08-30)Aim This scoping review aims to explore the effect of FSS and mental simulation on the decision-making skills of nursing students. Background Full-scale simulation (FSS) has been the most used simulation modality in nursing ...