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2-oxothiazolidine-4-carboxylic acid inhibits vascular calcification via induction of glutathione synthesis
Patel, Jessal; Bourne, Lucie E; Thakur, Shori; Farrington, Kenneth; Gorog, Diana; Orriss, Isabel R; Baydoun, Anwar (2020-09-12)Arterial medial calcification (AMC), the deposition of hydroxyapatite in the medial layer of the arteries, is a known risk factor for cardiovascular events. Oxidative stress is a known inducer of AMC and endogenous ... -
3,4-methylenedioxymethamphetamine (ecstasy) inhibits dyskinesia expression and normalizes motor activity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates
Iravani, Mahmoud M.; Jackson, M. J.; Kuoppamaki, M.; Smith, L. A.; Jenner, P. (2003-10-08)Ecstasy [3,4-methylenedioxymethamphetamine (MDMA)] was shown to prolong the action of L-3,4-dihydroxyphenylalanine (L-DOPA) while suppressing dyskinesia in a single patient with Parkinson's disease (PD). The clinical basis ... -
3-Nitrotyrosine-dependent dopaminergic neurotoxicity following direct nigral administration of a peroxynitrite but not a nitric oxide donor
Iravani, Mahmoud M.; Haddon, C. O.; Rose, S.; Jenner, P. (2006-01-05)The presence of 3-nitrotyrosine (3-NT) adducts in Lewy bodies in Parkinson's disease suggests a role for nitrative stress in dopaminergic cell death. Whether this is a direct effect of increased nitric oxide (NO) formation ... -
3D Characterisation of Dry Powder Inhaler Formulations: Developing X-ray Micro Computed Tomography Approaches
Gajjar, P; Styliari, I D; Nguyen, T T H; Carr, J; Chen, X; Elliott, J A; Hammond, R B; Burnett, T L; Roberts, K; Withers, P J; Murnane, D (2020-06)Carrier-based dry powder inhaler (DPI) formulations need to be accurately characterised for their particle size distributions, surface roughnesses, fines contents and flow properties. Understanding the micro-structure of ... -
[3H]2-(2-Benzofuranyl)-2-imidazoline : a new selective high affinity radioligand for the study of rabbit brain imidazoline I2 receptors
Lione, Lisa; Nutt, D.J.; Hudson, A.L. (1996-05)This is the first study characterising the binding of the new imidazoline I2 receptor selective radioligand [3H]2-(2-benzofuranyl)-2-imidazoline (2-BFI) to rabbit brain membranes. [3H]2-BFI binding was found to be saturable ... -
5,6-Methylenedioxy-2-aminoindane : from laboratory curiosity to 'legal high'
Gallagher, C. T.; Assi, S.; Stair, J. L.; Fergus, S.; Corazza, Ornella; Corkery, John; Schifano, Fabrizio (2012-03-01)The fully synthetic 'legal high' 5,6-methylenedioxy-2-aminoindane (MDAI) is an analogue of 3,4-methylenedioxymethamphetamine. Although developed in the 1990s, it was not widely abused until 2010. However, mephedrone was ... -
Abnormal synaptic plasticity and impaired spatial cognition in mice transgenic for exon 1 of the human Huntington's disease mutation
Murphy, K. P. S. J.; Carter, R. J.; Mangiarini, L.; Mahal, A.; Bates, G. P.; Dunnett, S.B.; Morton, A. J.; Lione, Lisa (2000-07-01)Huntington's disease (HD) is an autosomal dominant progressive and fatal neurodegenerative brain disorder caused by an expanded CAG/polyglutamine repeat in the coding region of the gene. Presymptomatic Huntington's disease ... -
Absorption of the nerve agent VX (O-ethyl-S-[2(di-isopropylamino)ethyl] methyl phosphonothioate) through pig, human and guinea pig skin in vitro
Dalton, Christopher H.; Hattersley, Ian J.; Rutter, Stephen J.; Chilcott, Robert (2006-12)The physico-chemical properties of VX make the skin the most likely route of absorption into the human body. The development of effective medical countermeasures against such percutaneous threat agents relies on the use ... -
Acceptability in the Older Population: The Importance of an Appropriate Tablet Size
Vallet, Thibault; Michelon , Hugues; Orlu, Mine; Jani, Yogini Hariprasad; Leglise , Patrick; Laribe-Caget , Sandra; Piccoli, Matthieu; Le Fur , Aurélie; Liu, Fang; Ruiz , Fabrice; Boudy , Vincent (2020-08-08)Presenting many advantages, solid oral dosage forms (SODFs) are widely manufactured and frequently prescribed in older populations regardless of the specific characteristics of patients. Commonly, patients with dysphagia ... -
Accuracy of Diagnostic Judgments Using ICD-11 vs. ICD-10 Diagnostic Guidelines for Obsessive-Compulsive and Related Disorders
Kogan, Cary; Stein, Dan J.; Rebello, Tahilia; Keeley, Jared; Jacky Chan, K; Fineberg, Naomi; Fontenelle, Leonardo F.; Grant, Jon E; Matsunaga, Hisato; Blair Simpson, H; Thomsen, Per Hove; van den Heuvel, Odile; Veale, David; Grenier, Jean; Kulygina, Mayya; Matsumoto, Chihiro; Domínguez-Martínez, Tecelli; Stona, Anne-Claire (2020-08)Background: We report results of an internet-based field study evaluating the diagnostic guidelines for the newly introduced ICD-11 grouping of obsessive-compulsive and related disorders (OCRD). We examined accuracy of ... -
Activity of vancomycin against epidemic Clostridium difficile strains in a human gut model
Baines, Simon D.; O'Connor, Rachel; Saxton, Katie; Freeman, Jane; Wilcox, M. H. (2009)Vancomycin and metronidazole remain the only primary options for the treatment of Clostridium difficile infection (CDI). Recent reports have suggested a superior clinical response to vancomycin therapy compared with ... -
The acute and the long-term effects of nigral lipopolysaccharide administration on dopaminergic dysfunction and glial cell activation
Iravani, Mahmoud M.; Leung, Clement C. M.; Sadeghian, Mona; Haddon, C. O.; Rose, Sarah; Jenner, P. (2005-07)Sustained reactive microgliosis may contribute to the progressive degeneration of nigral dopaminergic neurons in Parkinson's disease (PD), in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exposed human and in non-human ... -
Advances in Problematic Usage of the Internet Research – A Narrative Review by Experts from the European Network for Problematic Usage of the Internet
Fineberg, Naomi; Menchon, Josè M; Hall, Natalie; Dell'Osso, Bernardo; Brand, Matthias; Potenza, Marc; Chamberlain, Samuel R; Cirnigliaro, Giovanna; Lochner, Christine; Billieux, Joël; Demetrovics, Zsolt; Rumpf, Hans Jürgen; Muller, Astrid; Castro-Calvo, Jesús; Hollander, Eric; Burkauskas, Julius; Grünblatt, Edna; Walitza, Susanne; Corazza, Ornella; King, Daniel L; Stein, Dan J.; Grant, Jon E; Pallanti, Stefano; Bowden-Jones, Henrietta; Van Ameringen, Michael; Ioannidis, Konstantinos; Carmi, Lior; Goudriaan, Anna E; Martinotti, Giovanni; Sales, Celia M; Jones, Julia; Gjoneska, Biljiana; Király, Orsolya; Benatti, Beatrice; Vismara, Matteo; Pellegrini, Lucas; Conti, Dario; Cataldo, Ilaria; Riva, Gianluigi M; Yücel, Murat; Flayelle, Maèva; Hall, Thomas; Griffiths, Morgan; Zohar, Joseph (2022-10-30)Global concern about problematic usage of the internet (PUI), and its public health and societal costs, continues to grow, sharpened in focus under the privations of the COVID-19 pandemic. This narrative review reports the ... -
Advantages and disadvantages of reciprocal peer-to-peer interviewing
Payne-Gifford, Sophie; Brueton, Rebecca; Hamilton, Gemma; Clark, Tessa; Chang, Yan-Shing; Gang, Parenting Science (2021)The advantages and disadvantages of reciprocal peer-to-peer interviewing as a data collection approachare presented in this paper. Reciprocal peer-to-peer interviewing is a research technique whereparticipants interview ... -
Afferent hypersensitivity in a mouse model of post-inflammatory gut dysfunction : role of altered serotonin metabolism
Keating, Christopher; Beyak, M.; Foley, S.; Singh, G.; Marsden, C.; Spiller, R.; Grundy, D. (2008-09)Visceral hypersensitivity is an important clinical feature associated with irritable bowel syndrome which in some patients has been linked to prior infection. Here we employ an animal model in which transient infection ... -
Age-associated changes in protein oxidation and proteasome activities in rat brain: Modulation by antioxidants
El Mohsen, M. M. A.; Iravani, Mahmoud M.; Spencer, J. P. E.; Rose, S.; Fahim, A. T.; Motawi, T. M. K.; Ismail, N. A. F.; Jenner, P. (2005-10-21)The free radical theory of ageing postulates that age-associated neurodegeneration is caused by an imbalance between pro-oxidants and antioxidants resulting in oxidative stress. The current study showed regional variation ... -
Ageing and gastrointestinal sensory function : altered colonic mechanosensory and chemosensory function in the aged mouse
Keating, Christopher; Grundy, David (2015)Ageing has a profound effect upon gastrointestinal function through mechanisms that are poorly understood (1). A feature of ageing is impaired sensory perception, including a diminished sensory response to inflammatory ... -
Ageing and Gastrointestinal Sensory Function : The Enteric Nervous System
Keating, Christopher; Grundy, David (2016-07-06)Over the past few decades a combination of electrophysiological, morphological and molecular approaches has enabled the different populations of vagal and spinal afferents that innervate the bowel to be characterized. The ... -
Ageing and gastrointestinal sensory function: altered colonic mechanosensory and chemosensory function in the aged mouse.
Keating, Christopher; Nochi, Linda; Yu, Yang; Donovan, Jemma; Grundy, D (2016-08-14)Ageing has a profound effect upon gastrointestinal function through mechanisms that are poorly understood. Here we investigated the effect of age upon gastrointestinal sensory signalling pathways in order to address the ... -
Alcohol/substance use and occupational/post-traumatic stress in paramedics
Hichisson, Andrew; Corkery, John (2020-10-02)Background: Paramedics work in high-pressure environments and experience traumatic events, which contribute to high levels of occupational and posttraumatic stress. Such stress can result in alcohol and substance misuse ...