- UHRA Home
- Browsing by Author
Browsing by Author "Khutoryanskiy, Vitaliy V."
Now showing items 1-14 of 14
-
Chitosan coated alginate beads for the survival of microencapsulated Lactobacillus plantarum in pomegranate juice
Nualkaekul, Sawaminee; Lenton, Dominique; Cook, Michael T.; Khutoryanskiy, Vitaliy V.; Charalampopoulos, Dimitris (2012-10-15)This work studied the effect of multi-layer coating of alginate beads on the survival of encapsulated Lactobacillus plantarum in simulated gastric solution and during storage in pomegranate juice at 4°C. Uncoated, single ... -
CLSM method for the dynamic observation of pH change within polymer matrices for oral delivery
Cook, Michael T.; Saratoon, Teedah; Tzortzis, George; Edwards, Alexander; Charalampopoulos, Dimitris; Khutoryanskiy, Vitaliy V. (2013-02-11)If acid-sensitive drugs or cells are administered orally, there is often a reduction in efficacy associated with gastric passage. Formulation into a polymer matrix is a potential method to improve their stability. The ... -
Influence of encapsulation and coating materials on the survival of Lactobacillus plantarum and Bifidobacterium longum in fruit juices
Nualkaekul, Sawaminee; Cook, Michael T.; Khutoryanskiy, Vitaliy V.; Charalampopoulos, Dimitris (2013-08-01)The aim of this work was to compare alginate and pectin beads for improving the survival of Lactobacillus plantarum and Bifidobacterium longum during storage in pomegranate and cranberry juice, and to evaluate the influence ... -
Investigation of milk proteins binding to the oral mucosa
Withers, Caroline A.; Cook, Michael T.; Methven, Lisa; Gosney, Margot A.; Khutoryanskiy, Vitaliy V. (2013-11-01)High protein dairy beverages are considered to be mouth drying. The drying sensation may be due to the product protein content; however the mechanism of this mouth drying is uncertain. This study investigated the potential ... -
Layer-by-layer coating of alginate matrices with chitosan-alginate for the improved survival and targeted delivery of probiotic bacteria after oral administration
Cook, Michael T.; Tzortzis, George; Khutoryanskiy, Vitaliy V.; Charalampopoulos, Dimitris (2013-01-07)The oral administration of probiotic bacteria has shown potential in clinical trials for the alleviation of specific disorders of the gastrointestinal tract. However, cells must be alive in order to exert these benefits. ... -
Microencapsulation of a synbiotic into PLGA/alginate multiparticulate gels
Cook, Michael T.; Tzortzis, George; Charalampopoulos, Dimitris; Khutoryanskiy, Vitaliy V. (2014-05-15)Probiotic bacteria have gained popularity as a defence against disorders of the bowel. However, the acid sensitivity of these cells results in a loss of viability during gastric passage and, consequently, a loss of efficacy. ... -
Microencapsulation of probiotics for gastrointestinal delivery
Cook, Michael T.; Tzortzis, George; Charalampopoulos, Dimitris; Khutoryanskiy, Vitaliy V. (2012-08-20)The administration of probiotic bacteria as nutraceuticals is an area that has rapidly expanded in recent years, with a global market worth $32.6 billion predicted by 2014. Many of the health promoting claims attributed ... -
Mucoadhesion and mucosa-mimetic materials - a mini-review
Cook, Michael T.; Khutoryanskiy, Vitaliy V. (2015-11-30)Mucoadhesion describes an attractive interaction between dosage form and mucosal membrane. The evaluation of mucoadhesive excipients often requires the use of ex vivo mucosal tissues taken from laboratory animals. These ... -
Novel glycopolymer hydrogels as mucosa-mimetic materials to reduce animal testing
Cook, Michael T.; Smith, Sarah L.; Khutoryanskiy, Vitaliy V. (2015-07-21)Glycopolymer hydrogels capable of mimicking mucosal tissue in mucoadhesion testing have been designed. Liquid formulations containing mucoadhesive polymers were found to be retained on these tissues to the same extent as ... -
Polymer Architecture Effects on Poly(N,N‐Diethyl Acrylamide)‐b‐Poly(Ethylene Glycol)‐b‐Poly(N,N‐Diethyl Acrylamide) Thermoreversible Gels and Their Evaluation as a Healthcare Material
Haddow, Peter J.; da Silva, Marcelo A.; Kaldybekov, Daulet B.; Dreiss, Cecile A.; Hoffman, Ewelina; Hutter, Victoria; Khutoryanskiy, Vitaliy V.; Kirton, Stewart B.; Mahmoudi, Najet; McAuley, William J.; Cook, Michael T. (2021-12-11)Thermoreversible gels which transition between liquid‐like and solid‐like states when warmed have enabled significant novel healthcare technologies. Poly(N,N‐diethyl acrylamide) (PDEA) is a thermoresponsive polymer which ... -
Production and evaluation of dry alginate-chitosan microcapsules as an enteric delivery vehicle for probiotic bacteria
Cook, Michael T.; Tzortzis, George; Charalampopoulos, Dimitris; Khutoryanskiy, Vitaliy V. (2011-07-11)This study investigates the production of alginate microcapsules, which have been coated with the polysaccharide chitosan, and evaluates some of their properties with the intention of improving the gastrointestinal viability ... -
Synthesis and solution properties of a temperature-responsive PNIPAM–b-PDMS–b-PNIPAM triblock copolymer
Cook, Michael; Filippov, Sergey K; Khutoryanskiy, Vitaliy V. (2017-08-31)In this paper, we report the synthesis and self-assembly of a novel thermoresponsive PNIPAM60–b-PDMS70–b-PNIPAM60 triblock copolymer in aqueous solution. The copolymer used a commercially available precursor modified with ... -
Synthesis of mucoadhesive thiol-bearing microgels from 2-(acetylthio) ethylacrylate and 2-hydroxyethylmethacrylate : novel drug delivery systems for chemotherapeutic agents to the bladder
Cook, Michael T.; Schmidt, S.A.; Lee, E.; Samprasit, W.; Opanasopit, P.; Khutoryanskiy, Vitaliy V. (2015-07-21)Thiol-bearing microgels have been synthesised from copolymerisation of 2-(acetylthio)ethylacrylate and 2-hydroxyethylmethacrylate, and subsequent deprotection using sodium thiomethoxide. The concentration of thiol groups ... -
Understanding the temperature induced aggregation of silica nanoparticles decorated with temperature-responsive polymers: can a small step in the chemical structure make a giant leap for a phase transition?
Mansfield, Edward D.H.; Filippov, Sergey K.; de la Rosa, Victor R.; Cook, Michael T.; Grillo, Isabelle; Hoogenboom, Richard; Williams, Adrian C.; Khutoryanskiy, Vitaliy V. (2021-05-15)Temperature-responsive nanomaterials have gained increasing interest over the past decade due their ability to undergo conformational changes in situ, in response to a change in temperature. One class of temperature-responsive ...