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Browsing by Author "Murnane, Darragh"
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Branched Copolymer Surfactants as Versatile Templates for Responsive Emulsifiers with Bespoke Temperature‐Triggered Emulsion‐Breaking or Gelation
Rajbanshi, Abhishek; Alves da Silva, Marcelo; Haslett, Niamh; Cranwell, Philippa; Cunningham, Neil; Mahmoudi, Najet; Murnane, Darragh; Pavlova, Ewa; Slouf, Miroslav; Dreiss, Cecile; Cook, Michael (2023-10-27)It has been found that the thermoresponsive behavior of emulsions stabilized by block copolymer surfactants (BCSs) can induce either gelation or emulsion break‐up with mild temperature changes. A hydrophilic, steric‐stabilizing ... -
Combining branched copolymers with additives generates stable thermoresponsive emulsions with in situ gelation upon exposure to body temperature
Rajbanshi, Abhishek; Mahmoudi, Najet; Murnane, Darragh; Pavlova, Ewa; Slouf, Miroslav; Dreiss, Cécile A.; Cook, Michael T. (2023-04-04)Branched copolymer surfactants (BCS) containing thermoresponsive polymer components, hydrophilic components, and hydrophobic termini allow the formation of emulsions which switch from liquid at room temperature to a gel ... -
Comparison of Oral, Intranasal and Aerosol Administration of Amiodarone in Rats as a Model of Pulmonary Phospholipidosis.
Bodhaniya, Aateka; Hoffman, Ewelina; Ball, Dough; Klapwijk, Jan; Steven, Rory T.; Dexter, Alex; Bunch, Josephine; Baker, Daniel; Murnane, Darragh; Hutter, Victoria; Page, Clive; Dailey, Lea Ann; Forbes, Ben (2019-07-17)‘Foamy’ alveolar macrophages (FAM) observed in nonclinical toxicology studies during inhaled drug development may indicate drug-induced phospholipidosis, but can also derive from adaptive non-adverse mechanisms. Orally ... -
Comparison of salmeterol xinafoate microparticle production by conventional and novel antisolvent crystallization
Murnane, Darragh; Marriott, Christopher; Martin, Gary P. (2008-05)The production of microparticles for inhalation has relied on jet-milling while the potential for crystallization of microparticles has remained underexplored until relatively recently. Aqueous antisolvent crystallization ... -
Concordance, adherence or competence – device use and therapeutic outcomes in older patients
Murnane, Darragh (2013)When looking at the needs of the older patient, several issues arise related to the use of medical devices and technologies. Making allowances for physical capacity and cognitive ability, for example, can be crucial to ... -
Crystallographic tomography and molecular modelling of structured organic polycrystalline powders
Gajjar, Parmesh; Nguyen, Thai T. H.; Sun, Jun; Styliari, Ioanna D.; Bale, Hrishikesh; McDonald, Samuel A.; Burnett, Timothy L.; Tordoff, Benjamin; Lauridsen, Erik; Hammond, Robert B.; Murnane, Darragh; Withers, Philip J.; Roberts, Kevin J. (2021-03-02)A fundamental understanding of the behaviour of polycrystalline materials, including pharmaceuticals, is vital for control of their physicochemical and crystalline properties, which in turn has the potential to improve ... -
Developing an environmentally benign process for the production of microparticles : Amphiphilic crystallization
Murnane, Darragh; Marriott, Christopher; Martin, Gary P. (2008-05)The production of microparticles for inhalation typically employs jet-milling which can be destructive to the solid-state properties of the particles. The objective of the current work was to develop a crystallization ... -
Development of a New Dislodgeable Foliar Residue Analytical Laboratory Method for Pesticides
Badawy, Mohamed; Murnane, Darragh; Lewis, Kathy; Morgan, Neil (2022-10-11)The dislodgeable foliar residue (DFR) is the amount of pesticide that exists on foliage after the pesticide has dried and which could dislodge to the skin or clothes of workers and is a key parameter for non-dietary risk ... -
Development of an adaptive bypass element for passive entrainment flow control in dry powder inhalers
Kopsch, Thomas; Murnane, Darragh; Symons, Digby (2019-08-01)The release of drug from dry powder inhalers is strongly dependent on the patient's inhalation profile. To maximise the effect of the treatment, it is necessary to optimise dry powder inhalers to achieve drug delivery that ... -
A digital workflow from crystallographic structure to single crystal particle attributes for predicting the formulation properties of terbutaline sulfate
Nguyen, Thai T. H.; Hammond, Robert B.; Styliari, Ioanna D.; Murnane, Darragh; Roberts, Kevin J. (2020-05-21)A detailed inter-molecular (synthonic) analysis of terbutaline sulfate, an ionic addition salt for inhalation drug formulation, is related to its crystal morphology, and through this to the surface chemistry of the habit ... -
Direct Ionization of Solid-Phase Microextraction Fibers for Quantitative Drug Bionalysis : From Peripheral Circulation to Mass Spectrometry Detection
Sheelan, Ahmad,; Michael, Tucker,; Neil, Spooner,; Murnane, Darragh; Gerhard, Ute (2015-01-06)A novel approach is described for the quantitative bioanalysis of drugs in blood samples by ionization of the analytes collected on solid-phase microextraction (SPME) fibers by mass spectrometry (MS). The technique combines ... -
Dispersing the Mists: An Experimental History of Medicine Study into the Quality of Volatile Inhalations
Murnane, Barry; Gallagher, Cathal; Snell, Noel; Sanders, Mark; Moshksar, Ramin; Murnane, Darragh (2017-06-01)Background: Dr. Nelson's Improved Inhaler was first marketed with an advertisement in The Lancet in 1865. Revolutionary at the time for its ease of use and patient-friendliness, the inhaler is still in use for self-treatment ... -
Dry Powder Formulations for Inhalation of Fluticasone Propionate and Salmeterol Xinafoate Microcrystals
Murnane, Darragh; Martin, Gary P.; Marriott, Christopher (2009-02)Direct crystallization of active pharmaceutical ingredient (API) particles in the inhalable size range of 1-6 mu m may overcome surface energization resulting from micronization. The aerosolization of fluticasone propionate ... -
Dynamics of aerosol size during inhalation : Hygroscopic growth of commercial nebulizer formulations
Haddrell, Allen E.; Davies, James F.; Miles, Rachael E. H.; Reid, Jonathan P.; Dailey, Lea Ann; Murnane, Darragh (2014-03-10)The size of aerosol particles prior to, and during, inhalation influences the site of deposition within the lung. As such, a detailed understanding of the hygroscopic growth of an aerosol during inhalation is necessary to ... -
Establishing the importance of oil-membrane interactions on the transmembrane diffusion of physicochemically diverse compounds
Najib, Omaima N.; Martin, Gary P; Kirton, Stewart; Sallam, Al-Sayed; Murnane, Darragh (2016-06-15)The diffusion process through a non-porous barrier membrane depends on the properties of the drug, vehicle and membrane. The aim of the current study was to investigate whether a series of oily vehicles might have the ... -
Evidence for the existence of powder sub-populations in micronized materials : Aerodynamic size-fractions of aerosolized powders possess distinct physicochemical properties
Jaffari, Sara; Forbes, Ben; Collins, Elizabeth; Khoo, Jiyi; Martin, Gary P.; Murnane, Darragh (2014-12-31)Purpose: To investigate the agglomeration behaviour of the fine (< 5.0 µm) and coarse (> 12.8 µm) particle fractions of salmeterol xinafoate (SX) and fluticasone propionate (FP) by isolating aerodynamic size fractions and ... -
Formulation pre-screening of inhalation powders using computational atom-atom systematic search method
Ramachandran, Vasuki; Murnane, Darragh; Hammond, Robert B.; Pickering, Jonathan; Roberts, Kevin J.; Soufian, Majeed; Forbes, Ben; Jaffari, Sara; Martin, Gary P.; Collins, Elizabeth; Pencheva, Klimentina (2015-01-05)The synthonic modeling approach provides a molecule-centered understanding of the surface properties of crystals. It has been applied extensively to understand crystallization processes. This study aimed to investigate the ... -
‘Great ease and simplicity of action’: Dr Nelson’s Inhaler and the origins of modern inhalation therapy
Murnane, Barry; Murnane, Darragh; Sanders, Mark; Snell, Noel (2017-11-10)Unveiled at the conclusion of a meeting of the Royal Medical and Chirurgical Society in 1861,[1] ‘Dr Nelson’s Improved Inhaler’ was one of the most important milestones in the genesis of reliable treatment of respiratory ... -
High Content Image Analysis as a Tool to Morphologically Distinguish Macrophage Activation and Determine Its Importance for Foamy Alveolar Macrophage Responses
Hoffman, Ewelina; Napieralska, Paulina; Mahendran, Rhamiya; Murnane, Darragh; Hutter, Victoria (2021-09-01)Introduction: Lung diseases are an increasing global health burden affecting millions of people worldwide. Only a few new inhaled medicines have reached the market in the last 30 years, in part due to foamy alveolar ... -
In situ and Ex situ analysis of salmeterol xinafoate microcrystal formation from poly(ethylene glycol) 400 - Water cosolvent mixtures
Murnane, Darragh; Marriott, Christopher; Martin, Gary P. (2008-06)Salmeterol xinafoate (SX) crystallization was investigated under different conditions of stirring, antisolvent addition, and supersaturation to identify factors limiting particle growth to enable the production of respirable ...