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Browsing by Author "Styliari, Ioanna Danai"
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Assessment of the effect of Cellets’ particle size on the flow in a Wurster fluid-bed coater via powder rheology
Mohylyuk, Valentyn; Styliari, Ioanna Danai; Novykov, Dmytryi; Pikett, Reiss; Dattani, Rajeev (2019-12)The main objective of this study was to investigate the effect of microcrystalline cellulose (MCC) spheres (Cellets) size effect on the powder properties to assess the possible impact of the Cellets’ size on the powder ... -
High‐Throughput Miniaturized Screening of Nanoparticle Formation via Inkjet Printing
Styliari, Ioanna Danai; Conte, Claudia; Pearce, Amanda; Huesler, Amanda; Cavanagh, Robert; Limo, Marion; Gordhan, Dipak; Nieto-Orellana, Alejandro; Suksiriworapong, Jiraphong; Couturaud, Benoit; Williams, Phil; Hook, Andrew; Alexander, Morgan R.; Garnett, Martin; Alexander, Cameron; Burley, Jonathan; Taresco, Vincenzo (2018-08-01)The self‐assembly of specific polymers into well‐defined nanoparticles (NPs) is of great interest to the pharmaceutical industry as the resultant materials can act as drug delivery vehicles. In this work, a high‐throughput ... -
Microstructural insight into inhalation powder blends through correlative multi-scale X-ray Computed Tomography
Gajjar, Parmesh; Styliari, Ioanna Danai; Legh-Land, Victoria; Bale, Hrishikesh; Tordoff, Benjamin; Withers, Philip; Murnane, Darragh (2023-10-30)Dry powder inhalers (DPI) are important for topical drug delivery to the lungs, but characterising the pre-aerosolised powder microstructure is a key initial step in understanding the post-aerosolised blend performance. ... -
Molecular Synthon Modelling Of Inhalation Pharmaceuticals: A Digital Approach To Understanding And Engineering Particle Surface Interactions
Nguyen, Thai T. H.; Hammond, Robert; Styliari, Ioanna Danai; Murnane, Darragh; Roberts, Kevin J. (2020-02-19) -
Multiscale Tomography: Probing The Nano-, Micro-, And Meso-Scale Resolution Of Inhalation Powder Structure
Gajjar, Parmesh; Styliari, Ioanna Danai; Burnett, Timothy; Chen, Xizhong; Elliot, James A.; Ganley, William J.; Hammond, Robbert; Nguyen, Hien; Price, Robert; Roberts, Kevin; Withers, Philip; Murnane, Darragh (Respiratory Drug Delivery, RDD, 2019-05-07)Understanding the agglomeration behavior of inhaled formulations is essential to ensure consistent aerosolization performance that maximizes drug deposition in the lower respiratory tract. Although many techniques are ... -
Nanoformulation-by-design: an experimental and molecular dynamics study for polymer coated drug nanoparticles
Styliari, Ioanna Danai; Taresco, Vincenzo; Theophilus, Andrew; Alexander, Cameron; Garnett, Martin C.; Laughton, Charles A. (2020-05-21)The formulation of drug compounds into nanoparticles has many potential advantages in enhancing bioavailability and improving therapeutic efficacy. However, few drug molecules will assemble into stable, well-defined ... -
On Measuring the Specific Surface Area of inhalation-grade lactose powders
Styliari, Ioanna Danai; Nguyen, Thai TH; Gajjar, Parmesh; Tordoff, Benjamin; Burnett, Timothy; Withers, Philip; Hammond, Robert B.; Roberts, Kevin J.; Murnane, Darragh (2020-01-28) -
Optimising poly(lactic-co-glycolic acid) microparticle fabrication using a Taguchi orthogonal array design-of-experiment approach
Mensah, Rosemond; Kirton, Stewart; Cook, Michael T.; Styliari, Ioanna Danai; Hutter, Victoria; Chau, David (2019-09-26)The objective of this study was to identify, understand and generate a Taguchi orthogonal array model for the formation of 10–50 μm microparticles with applications in topical/ocular controlled drug delivery. Poly(lactic ... -
Physicochemical characterisation of inhalation grade lactose after the removal of intrinsic fines
Styliari, Ioanna Danai; Mobli, Arian; Murnane, Darragh (2018-12-14)Lactose is a common excipient in Dry Powder Inhaler (DPI) formulations, used as a carrier for the micronized drug particles. The presence of intrinsic lactose fines in the formulation influences its performance and their ... -
Poly (glycerol adipate) (PGA), an enzymatically synthesized functionalizable polyester and versatile drug delivery carrier : A literature update
Swainson, Sadie M.E.; Styliari, Ioanna Danai; Taresco, Vincenzo; Garnett, Martin C. (2019-09-25)The enzymatically synthesized poly (glycerol adipate) (PGA) has demonstrated all the desirable key properties required from a performing biomaterial to be considered a versatile "polymeric-tool" in the broad field of drug ... -
Poly(triazolyl methacrylate) glycopolymers as potential targeted unimolecular nanocarriers
Madeira do O, J.; Foralosso, R.; Yilmaz, G.; Mastrotto, F.; King, P.J.S.; Xerri, R.M.; He, Y.; van der Walle, C.F.; Fernandez-Trillo, F.; Laughton, C. A.; Styliari, Ioanna Danai; Stolnik, S.; Mantovani, G. (2019-10-29)Synthetic glycopolymers are increasingly investigated as multivalent ligands for a range of biological and biomedical applications. This study indicates that glycopolymers with a fine-tuned balance between hydrophilic sugar ... -
Synthesis and properties of a biodegradable polymer-drug conjugate: Methotrexate-poly(glycerol adipate)
Suksiriworapong, Jiraphong; Taresco, Vincenzo; Ivanov, Delyan P.; Styliari, Ioanna Danai; Sakchaisrie, Krisada; Buraphacheep Junyapraserta, Varaporn; Garnett, Martin (2018-07-01)Polymer-drug conjugates have been actively developed as potential anticancer drug delivery systems. In this study, we report the first polymer-anticancer drug conjugate with poly(glycerol adipate) (PGA) through the successful ... -
Unlocking the Microstructure of Inhalation Blends using X-ray Microscopy
Gajjar, Parmesh; Bale, Hrishikesh; Burnett, Timothy; Chen, Xizhong; Elliot, James A.; Gomez, Herminso Villarraga; Hammond, Robert B.; Nguyen, Hien; Roberts, Kevin J.; Styliari, Ioanna Danai; Tordoff, Benjamin; Withers, Philip; Murnane, Darragh (Respiratory Drug Delivery, RDD, 2020-04-26)Microstructural equivalence (Q3) for dry powder inhalers (DPIs) is complex because it involves both pre- and post-aerosolization powders and can be influenced by the DPI device and the patient’s aerosolization efficiency. In ...