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Browsing by Author "Traynor, M.J."
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Classification of irritant/ non-irritant and corrosive chemicals using excised human skin in vitro
Stewart, C.A.; Turner, Rob B.; Brown, Marc; Traynor, M.J. (Royal Society of Chemistry, 2014-04-14)Any chemical that is applied to the skin has the potential to induce a skin reaction. These reactions are complicated and are difficult to fully replicate in vitro and may exhibit species variations when reproduced in vivo. ... -
Collection and characterisation of residual skin surface components obtained from sebum, sweat and epidermal lipids
Shetage, S.S.; Traynor, M.J.; Brown, Marc; Chilcott, Robert (Royal Society of Chemistry, 2014-04-14)Collection and analysis of skin surface lipids or sebum has been reported in several previous studies where Sebutape™, polyurethane foam, cigarette paper and organic solvents were used to acquire samples, analysis of which ... -
Effect of a novel penetration enhancer on the ungual permeation of two antifungal agents
Traynor, M.J.; Turner, R. B.; Evans, C.R.G.; Khengar, R. H.; Jones, S. A.; Brown, Marc (2010-06)Objectives The aim of this study was to demonstrate the effect of a novel permeation enhancer system using two existing marketed nail lacquers and the delivery of terbinafine through human nail samples in vitro. Methods ... -
Effect of a novel penetration enhancer system on the ungual permeation of antifungal agents
Griffith, H. M. T.; Traynor, M.J.; Turner, R. B.; Evans, C. R. G.; Khengar, R. H.; Jones, S. A.; Brown, Marc (2010-06) -
The effect of disulphide bond disruption on the barrier integrity of the human nail
Baraldi, A.; Khengar, R.H.; Murdan, S.; Traynor, M.J.; Jones, S.A.; Brown, Marc (Royal Society of Chemistry, 2014-04-14)Onychomycosis is the fungal infection of the nail and accounts for approximately 50% of all nail disorders [1]. The prevalence of onychomycosis is increasing and currently up to 10 % of people in the UK and US are reported ... -
Effect of ethnicity, gender and age on the amount and composition of residual skin surface components derived from sebum, sweat and epidermal lipids
Shetage, Satyajit; Traynor, M.J.; Brown, Marc; Raji, Mahad; Graham-Kalio, Diepiriyie; Chilcott, Robert (2014-02)Background/purpose: The superficial layer on the skin surface, known as the acid mantle, comprises a mixture of sebum, sweat, corneocyte debris and constituents of natural moisturizing factor. Thus, the phrase 'residual ... -
Efficacy, tolerability and consumer acceptability of terbinafine topical spray versus terbinafine topical solution : a phase IIa randomised, observer-blind, comparative study
Brown, Marc; Evans, Charles; Muddle, Andrew; Turner, Rob; Lim, Sian; Reid, Jessica; Traynor, M.J. (2013-10)Tinea pedis is one of the world's most prevalent dermatophyte infections. MedSprayTM tinea pedis 1 % w/w (topical spray) is a novel, easy to use propellant based spray formulation containing 1% w/w terbinafine, requiring ... -
Free radical facilitated damage of ungual keratin
Khengar, Rajeshree H.; Brown, Marc; Turner, Rob B.; Traynor, M.J.; Holt, Katherine B.; Jones, Stuart A. (2010-09-01)Thioglycolic acid (TA) and urea hydrogen peroxide (urea H2O2) are thought to disrupt alpha-keratin disulfide links in the nail However, optimal clinical use of these agents to improve the treatment of nail disorders is ... -
Human Nail Plate Modifications Induced by Onychomycosis : Implications for Topical Therapy
Baraldi, A.; Jones, S. A.; Guesné, S.; Traynor, M.J.; McAuley, W. J.; Brown, Marc; Murdan, S. (2015-05-01)Conclusions: Onchomycotic nails presented a thicker but more porous barrier, and its eroded intracellular matrix rendered the tissue more permeable to topically applied chemicals when an aqueous vehicle was used.Purpose: ... -
Influence of alcohol on the release of tramadol from 24-h controlled-release formulations during in vitro dissolution experiments
Traynor, M.J.; Brown, Marc; Pannala, A.; Beck, P.; Martin, G. P. (2008)Recent warnings by regulatory bodies and a product recall by the FDA have generated much interest in the area of dose dumping from controlled-release opioid analgesic formulations when coingested with alcohol. It was the ... -
The influence of water mixtures on the dermal absorption of glycol ethers
Traynor, M.J.; Wilkinson, S.C.; Williams, F.M. (2007)Glycol ethers are solvents widely used alone and as mixtures in industrial and household products. Some glycol ethers have been shown to have a range of toxic effects in humans following absorption and metabolism to their ... -
Investigation into the functionality of controlled drug denaturing/destruction kits
Traynor, M.J. (2015-03)Context: Throughout the UK a large amount of unwanted, expired or patient returned controlled drugs are disposed of every day, in community and hospital pharmacies, veterinary surgeries, hospices, private hospitals and ... -
An investigation of how fungal infection influences drug penetration through onychomycosis patient's nail plates
McAuley, W. J.; Jones, S. A.; Traynor, M.J.; Guesné, S.; Murdan, S.; Brown, Marc (2016-05)The treatment of onychomycosis remains problematic even though there are several potent antifungal agents available for patient use. The aim of this investigation was to understand if the structural modifications that arise ... -
Is ivrt alone sufficient to demonstrate 'sameness' of generic products?
Traynor, M.J.; Shetage, Satyajit S.; Wood, Daniel G.; Brown, Marc (Royal Society of Chemistry, 2014-04) -
Metabolism of Butoxyethanol in excised human skin in vitro
Traynor, M.J.; Wilkinson, S.C.; Williams, F.M. (2008)Glycol ethers are widely used in industrial and household applications because their chemical and physical properties make them versatile solvents, miscible with both water and organic media. Due to the ease with which the ... -
Overcoming the nail barrier : A systematic investigation of ungual chemical penetration enhancement
Brown, Marc; Khengar, Rajeshree H.; Turner, Rob B.; Forbes, B.; Traynor, M.J.; Evans, C.R.G.; Jones, S. A. (2009-03-31)This study investigated the in vitro nail permeability of penetrants of varying lipophilicity—caffeine (CF, log P −0.07), methylparaben (MP, log P 1.96) and terbinafine (TBF, log P 3.3) and the effect of 2 novel penetration ... -
Pharmacokinetic evaluation of intranasally administered vinyl coated lorazepam microparticles in rabbits
Zhao, Yanjun; Khengar, Raj; Traynor, M.J.; Barata, Pedro; Brown, Marc; Jones, Stuart (2012)The intranasal (IN) administration of lorazepam is desirable in order to maximize speed of onset and minimise carry-over sedation; however, this benzodiazepine is prone to chemical hydrolysis and poor airway retention, and ... -
A phase II study of the efficacy, tolerability and consumer acceptability of a 1% w/w terbinafine topical spray versus a currently marketed terbinafine product in the once only treatment of tinea pedis
Evans, C.; Brown, Marc; Traynor, M.J.; Lim, S.; Turner, R. J. (2010-06)A novel topical metered dose aerosol (MDA) spray that delivers terbinafine hydrochloride to human skin for the treatment of tinea pedis (athlete's foot) has been developed. The drug product is manufactured as a solution ... -
Transdermal drug delivery devices : Skin perturbation devices
Brown, Marc; Traynor, M.J.; Martin, Gary; Akomeah, Franklin (2008) -
Transdermal drug delivery devices: Skin perturbation systems
Brown, M.B.; Traynor, M.J.; Martin, G.P.; Akomeah, F.K. (Springer (Humana Press), 2008)Human skin serves a protective function by imposing physicochemical limitations to the type of permeant that can traverse the barrier. For a drug to be delivered passively via the skin it needs to have a suitable lipophilicity ...