Browsing Research publications by Author "Pharmacology and Clinical Science Research"
Now showing items 41-60 of 107
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The high-force region of the force-velocity relation in frog skinned muscle fibres
Lou, Fang; Sun, Y-B. (1993-07)The force-velocity relation has been studied during calcium-induced contracture of chemically skinned fibres from the semitendinosus muscle of Rana temporaria with special interest focused on the high-load region. The ... -
Homeostatic role of toll-like receptor 4 in the endothelium and heart
Harrington, L.S.; Belcher, E.; Moreno, L.; Mitchell, J.A.; Carrier, M.J. (2007-12)Toll-like receptor 4 (TLR4) is a pattern recognition receptor for lipopolysaccharide from Gram negative bacteria and thus is integral to the innate immune response in mammals. In addition, TLR4 is associated with atherosclerosis ... -
How Robust Is the 'Surprise Question' in Predicting Short-Term Mortality Risk in Haemodialysis Patients?
Da Silva Gane, Maria; Braun, Andreas; Stott, David; Wellsted, D.; Farrington, Ken (2013-08-06)Background/Aims: The 'surprise question' (SQ) may aid timely identification of patients with end-of-life care needs. We assessed its prognostic value and variability among clinicians caring for a cohort of haemodialysis ... -
Human uraemic serum displays calcific potential in vitro that increases with advancing chronic kidney disease
Patidar, Ashish; Singh, Dhruv; Winocour, Peter; Farrington, Ken; Baydoun, A. R. (2013-03)Vascular calcification strongly correlates with declining renal function and contributes to the high morbidity and mortality of patients with chronic kidney disease (CKD). It is closely regulated by circulating factors but ... -
A hyperspectral fluorescence lifetime probe for skin cancer diagnosis
De Beule, P A A; Dunsby, C; Galletly, N P; Stamp, G W; Chu, A C; Anand, U; Anand, P; Benham, C.D.; Naylor, A; French, P M W (2007)The autofluorescence of biological tissue can be exploited for the detection and diagnosis of disease but, to date, its complex nature and relatively weak signal levels have impeded its widespread application in biology ... -
‘I feel weak, useless and dependent on others’ : South Asian patient experiences of haemodialysis
Sharma, Shivani; Mooney, Roisin; Davenport, Andrew; Day, Clara; Duncan, Neil; Wellsted, D.; Da Silva Gane, Maria; Modi, Kirit; Farrington, Ken (2015-06-30)OBJECTIVE: Much of what is known about patient experiences of haemodialysis (HD) has been gleaned from research with White English speaking groups. People from South Asian backgrounds- originating from India, Pakistan and ... -
Identifying depression in South Asian patients with end-stage renal disease : Considerations for practice
Sharma, Shivani; Bhui, Kamaldeep; Chilcot, Joseph; Wellsted, D.; Farrington, Ken (2011-12)Depression is a prevalent burden for patients with end-stage renal disease (ESRD) and one that is under-recognized and consequently under-treated. Although several studies have explored the association between depression ... -
Illness perceptions predict survival in haemodialysis patients
Chilcot, J.; Wellsted, D.; Farrington, Ken (2011)Background : Illness perceptions have been shown to be important determinants of functional and psychosocial outcomes, including quality of life and treatment adherence in end-stage renal disease patients. The aim of this ... -
Illness representations and concurrent depression symptoms in haemodialysis patients
Chilcot, Joseph; Wellsted, D.; Davenport, Andrew; Farrington, Ken (2011)We examined the association between illness perceptions and depression symptoms in established haemodialysis patients (HD). Two hundred and fifteen patients completed the Revised Illness Perception Questionnaire and the ... -
The impact of national chronic kidney disease management guidelines in the United Kingdom on referral patterns for South Asian and european patients with type 2 diabetes mellitus
Wilkinson, Emma; Randhawa, Gurch; Hall, Matt; Lightstone, Liz; Farrington, Ken; Greenwood, Roger; Roderick, Paul; Feehally, John (Nova Science Publishers Inc., USA., 2013-12-01)Background: South Asian patients with type 2 diabetes mellitus in the United Kingdom are over 10 times more likely to progress to end-stage renal disease than European patients. It is unclear whether this is due to late ... -
Impaired thrombolytic status predicts adverse cardiac events in patients undergoing primary percutaneous coronary intervention
Christopoulos, Christos; Farag, Mohamed; Sullivan, Keith; Wellsted, David; Gorog, Diana A (2017-03-01)Antithrombotic medications reduce thrombosis but increase bleeding. Identification of ST-elevation myocardial infarction (STEMI) patients at risk of recurrent thrombosis could allow targeted treatment with potent antithrombotic ... -
In silico modelling of prostacyclin and other lipid mediators to nuclear receptors reveal novel thyroid hormone beta receptor antagonist properties.
Perez Diaz, Noelia; Zloh, Mire; Patel, Pryank; MacKenzie, Louise Susan (2016-01-01)Prostacyclin (PGI2) is a key mediator involved in cardiovascular homeostasis, acting predominantly on two receptor types; cell surface IP receptor and cytosolic peroxisome proliferator activated receptor (PPAR) β/δ. Having ... -
Introduction to electronic voting systems: how to use TurningPoint
Lou, Fang; Lorimer, J. (2010)The place of formative assessment within learning has long been established (Draper 2009, Nicol and Mcfarlane-Dick, 2006) and electronic voting systems (EVS) are an easy to use technology that allows lecturers to incorporate ... -
Is there a rationale for rationing chronic dialysis? : A hospital based cohort study of factors affecting survival and morbidity
Chandna, S.M.; Schulz, J.; Lawrence, C.; Greenwood, R.N.; Farrington, Ken (1999-01-23)Objectives To determine factors influencing survival and need for hospitalisation in patients needing dialysis, and to define the potential basis for rationing access to renal replacement therapy. Design Hospital based ... -
Is There Long-Term Clinical Equipoise Between CABG and PCI for Isolated Left Anterior Descending Artery Disease?
Navarese, Eliano P.; Ruscio, Eleonora; Gorog, Diana A. (2023-07-27) -
Isometric and isovelocity contractile performance of red muscle fibres from the dogfish Scyliorhinus canicula
Lou, Fang; Curtin, N.A.; Woledge, R.C. (2002-06)Maximum isometric tetanic force produced by bundles of red muscle fibres from dogfish, Scyliorhinus canicula (L.), was 142.4+/-10.3 kN m(-2) (N=35 fibre bundles); this was significantly less than that produced by white ... -
Lack of awareness of kidney complications despite familiarity with diabetes : a multi-ethnic qualitative study
Wilkinson, E.; Randhawa, G.; Farrington, Ken; Greenwood, R.N.; Feehally, J.; Choi, P.; Lightstone, L. (2011)Background: Comparing South Asians with White Europeans and examining the cultural context of any observed differences is a necessary step in achieving culturally competent services and in helping to reduce inequalities ... -
LC-MS/MS Confirms That COX-1 Drives Vascular Prostacyclin Whilst Gene Expression Pattern Reveals Non-Vascular Sites of COX-2 Expression
Kirkby, N.S.; Zaiss, A.K.; Urquhart, P.; Jiao, J.; Austin, P.J.; Al-Yamani, Malak; Lundberg, M.H.; MacKenzie, Louise; Warner, T.D.; Nicolaou, A.; Herschman, H.R.; Mitchell, J.A. (2013-07-09)There are two schools of thought regarding the cyclooxygenase (COX) isoform active in the vasculature. Using urinary prostacyclin markers some groups have proposed that vascular COX-2 drives prostacyclin release. In contrast, ... -
Linking Induction and Transrepression of PPARβ/δ with Cellular Function
Perez Diaz, Noelia; MacKenzie, Louise Susan (2015-01-26)Peroxisome proliferator activated receptors (PPARs) are ligand-activated transcription factors and members of the nuclear hormone receptor superfamily. PPARβ/δ is ubiquitously expressed and has a central role in homeostasis, ... -
Linking Phospholipase C isoforms with differentiation function in human vascular smooth muscle cells
MacKenzie, Louise Susan; Lymn, Joanne; Hughes, Alun D. (2013-12)The phosphoinositol phospholipase C (PLC) family of enzymes consists of a number of isoforms, each of which has different cellular functions. PLCγ1 is primarily linked to tyrosine kinase transduction pathways, whereas PLCδ1 ...