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Browsing by Author "Centre for Research in Mechanisms of Disease and Drug Discovery"
Now showing items 341-360 of 435
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Quantitative determination of single-bead metal content from a peptide combinatorial library
Stair, Jacqueline L.; White, Brianna R.; Rowland, Adam; Holcombe, James A. (2006-11-13)An electrothermal vaporizer inductively coupled plasma mass spectrometer (ETV-ICPMS) was used to quantitatively screen metals bound to single polystyrene (TentaGel) beads with immobilized oligopeptides. Tests were performed ... -
Racemic 9,10-dimethoxy-3-methyl-6-phenyl-7,7a-dihydrobenzo[b]benzo[4,5]isothiazolo[2,3-d][1,4]diazepine 12,12-dioxide
Bassin, J.P.; Shah, V.P.; Martin, L.; Horton, P.N. (2011)There are two molecules in the asymmetric unit of the title compound, C24H22N2O4S. The conformation of the seven-membered ring is twisted boat for both molecules. The molecule is chiral, but crystal symmetry generates a ... -
Raman spectroscopy coupled to computational approaches towards understanding self-assembly in thermoreversible poloxamer gels
Cook, Michael T.; Abou Shamat, Mohamad; Stair, Jacqueline; Calvo-Castro, Jesus (2022-02-03)The exploitation of vibrational spectroscopy approaches towards the understanding of molecular-level events in polymers, such as poloxamers, is highly warranted. This would facilitate the development of real-time approaches ... -
Randomized clinical trial to evaluate the effect of fecal microbiota transplant for initial Clostridium difficile infection in intestinal microbiome
Camacho-Ortiz, Adrian; Gutierrez-Delgado, Eva Maria; Garcia-Mazcorro, Jose F; Mendoza-Olazaran, Soraya; Adrian Martinez-Melendez, Adrian; Palau-Davila, Laura; Baines, Simon; Maldonado-Garza, Hector; Garza-Gonzalez, Elvira (2017-12-20)Objective The aim of this study was to evaluate the impact of fecal donor-unrelated donor mix (FMT-FURM) transplantation as first-line therapy for C. difficile infection (CDI) in intestinal microbiome. Methods We designed ... -
Re-sensitization of Mycobacterium smegmatis to Rifampicin Using CRISPR Interference Demonstrates Its Utility for the Study of Non-essential Drug Resistance Traits
Faulkner, Valwynne; Cox, Adrienne; Goh, Shan; van Bohemen, Annelies; Gibson, Amanda; Liebster, Oliver; Wren, Brendan; Willcocks, Sam; Kendall, Sharon (2021-02-01)A greater understanding of the genes involved in antibiotic resistance in Mycobacterium tuberculosis (Mtb) is necessary for the design of improved therapies. Clustered regularly interspaced short palindromic repeat ... -
Reactivity toward thiols and cytotoxicity of 3-methylene-2-oxindoles, cytotoxins from indole-3-acetic acids, on activation by peroxidases
Folkes, L.K.; Rossiter, S.; Wardman, P. (2002) -
Real-time effects of N-methyl-D-aspartic acid on dopamine release in slices of rat caudate putamen : A study using fast cyclic voltammetry
Iravani, Mahmoud M.; Kruk, Z. L. (1996-03)The functional role of N-methyl-D-aspartic acid (NMDA) glutamate receptors in the real-time regulation of single electrical pulse (1 p)-stimulated endogenous dopamine release was investigated in slices of rat caudate putamen ... -
Real-time measurement of stimulated 5-hydroxytryptamine release in rat substantia nigra pars reticulata brain slices
Iravani, Mahmoud M.; Kruk, Z. L. (1997-01)Fast cyclic voltammetry at a carbon fibre microelectrode was used to measure 5-HT signals following electrical or chemical stimulation in rat substantia nigra pars reticulata slices. Chemical stimulation with (+)-amphetamine ... -
Recent discoveries of influenza A drug target sites to combat virus replication
Patel, Hershna; Kukol, Andreas (2016-06-09)Sequence variations in the binding sites of influenza A proteins are known to limit the effectiveness of current antiviral drugs. Clinically, this leads to increased rates of virus transmission and pathogenicity. Potential ... -
Regulation of the Cardiac Na+/K+ ATPase by Phospholemman
Dhayan, Hansraj; Kumar, Rajender; Kukol, Andreas (Springer Nature, 2016) -
Repo-Man/protein phosphatase 1 SUMOylation mediates binding to lamin A and serine 22 dephosphorylation
Huguet, Florentin; Gokan, Ezgi; Foster, Helen A.; Amin, Hasnat A.; Vagnarelli, Paola (2022-04-13)Lamin A phosphorylation/de-phosphorylation is an important process during cells division as it allows for nuclear envelope (NE) disassembly at mitotic entry and its re-assembly during mitotic exit. Several kinases have ... -
Revisiting the General Solubility Equation : In Silico Prediction of Aqueous Solubility Incorporating the Effect of Topographical Polar Surface Area
Ali, Jogoth; Camilleri, Patrick; Brown, Marc; Hutt, Andrew J.; Kirton, Stewart B. (2012-02)The General Solubility Equation (GSE) is a QSPR model based on the melting point and log P of a chemical substance. It is used to predict the aqueous solubility of nonionizable chemical compounds. However, its reliance on ... -
RNA isolation and quantitative PCR from HOPE- and formalin-fixed bovine lymph node tissues
Witchell, J.; Varshney, D.; Gajjar, T.; Wangoo, A.; Goyal, M. (2008)The use of RNA extracted from HOPE fixed tissues in quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) is fairly novel. We compared qRT-PCR analysis of formalin and HOPE fixed, paraffin embedded lymph ... -
A role for core planar polarity proteins in cell contact-mediated orientation of planar cell division across the mammalian embryonic skin
Oozeer, Fazal; Yates, Laura; Dean, Charlotte; Formstone, Caroline (2017-05-12)The question of how cell division orientation is determined is fundamentally important for understanding tissue and organ shape in both healthy or disease conditions. Here we provide evidence for cell contact-dependent ... -
Role of inducible nitric oxide synthase in N-methyl-D-aspartic acid-induced strio-nigral degeneration
Iravani, Mahmoud M.; Liu, L.; Rose, S.; Jenner, P. (2004-12-10)N-Methyl-D-aspartate (NMDA)-induced striatal excitotoxicity is mediated by nitric oxide (NO) but the role of inflammatory mechanisms and inducible nitric oxide synthase (iNOS) induction is not clear. Unilateral intrastriatal ... -
The role of ventral tegmental dopamine neurons in locomotor sensitization following quinpirole or (+)-amphetamine : Ex vivo voltammetric evidence
Muscat, R.; Iravani, Mahmoud M.; Kruk, Z. L. (1996-12)Behavioural sensitization to the locomotor stimulating effects of (+)-amphetamine or quinpirole was induced in rats by intermittent drug administration. Following expression of sensitization, locomotor activity scores on ... -
SASP: targeted delivery to Gram-negative pathogens
Wang, H.; Hatzixanthis, K.; Barnard, A.; Shah, R.; Saveri, E.; Pitts, K.; Piwowarczyk, D.; Patil, G.; Baines, Simon D.; Wilkinson, A.; Fairhead, H. (2011-09)Background: Gram-negative bacteria are responsible for significant morbidity and mortality worldwide. Multi-drug resistance emergence has rendered many therapies ineffective. New therapies are urgently required to widen ... -
Secondary structure, orientation, and oligomerization of phospholemman, a cardiac transmembrane protein
Beevers, A.J.; Kukol, A. (2006) -
Selective discrimination learning impairments in mice expressing the human Huntington's disease mutation
Lione, Lisa; Carter, R. J.; Hunt, M. J.; Bates, G. P.; Morton, A. J.; Dunnett, S B (1999-12-01)Cognitive decline is apparent in the early stages of Huntington's disease and progressively worsens throughout the course of the disease. Expression of the human Huntington's disease mutation in mice (R6/2 line) causes a ... -
Selective inhibition of NADPH Oxidase reverses the over contraction of diabetic rat aorta
Rehman, Atif ur; Dugic, Elma; Benham, Christopher; Lione, Lisa; MacKenzie, Louise Susan (2014)Abnormal vascular responsiveness in diabetes has been attributed to a number of changes in contractile pathways, affected in part by the overproduction of reactive oxygen species (ROS). It has been reported that NADPH ...