Browsing by Title
Now showing items 3731-3750 of 24266
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Computational classification models for predicting the interaction of drugs with P-glycoprotein and breast cancer resistance protein
(2014-12)P-glycoprotein (P-gp/ABCB1) and breast cancer resistance protein (BCRP/ABCG2) are two members of the adenosine triphosphate (ATP) binding cassette (ABC) family of transporters which function as membrane efflux transporters ... -
Computational design principles for bioactive dendrimer based constructs as antagonists of the TLR4-MD-2-LPS complex
(2011-11-01)The cell surface interaction between bacterial lipopolysaccharide (LPS), Toll-like receptor 4 (TLR4) and MD-2 is central to bacterial sepsis syndromes and wound healing. We have shown that a generation (G) 3.5 polyamidoamine ... -
Computational exploration of molecular receptive fields in the olfactory bulb reveals a glomerulus-centric chemical map
(2020-01-09)Progress in olfaction is currently hampered by incomplete knowledge about chemical receptive ranges of primary receptors. Moreover, the chemical logic underlying the arrangement of computational units in the olfactory bulb ... -
Computational exploration of molecular receptive fields in the olfactory bulb reveals a glomerulus-centric chemical map
(2020-01-09)Progress in olfactory research is currently hampered by incomplete knowledge about chemical receptive ranges of primary receptors. Moreover, the chemical logic underlying the arrangement of computational units in the ... -
Computational Intelligence in Electrophysiology: Trends and Open Problems
(Springer Nature, 2008)This chapter constitutes mini-proceedings of the Workshop on Physiology Databases and Analysis Software that was a part of the Annual Computational Neuroscience Meeting CNS*2007 that took place in July 2007 in Toronto, ... -
Computational memory architectures for autobiographic agents interacting in a complex virtual environment : a working model
(2008)In this paper, we discuss the concept of autobiographic agent and how memory may extend an agent's temporal horizon and increase its adaptability. These concepts are applied to an implementation of a scenario where agents ... -
Computational Memory Architectures for Autobiographic and Narrative Virtual Agents
(2005-10)This thesis develops computational memory architectures for autobiographic and narrative virtual agents. Humans and many animals naturally possess a sophisticated memory system for reasoning, learning and also sharing ... -
Computational memory architectures for autobiographic and narrative virtual agents
(University of Hertfordshire, 2005)This thesis develops computational memory architectures for autobiographic and narrative virtual agents. Humans and many animals naturally possess a sophisticated memory system for reasoning, learning and also sharing ... -
Computational Model-Based Functional Magnetic Resonance Imaging of Reinforcement Learning in Humans
(2013-01-22)The aim of this thesis is to determine the changes in BOLD signal of the human brain during various stages of reinforcement learning. In order to accomplish that goal two probabilistic reinforcement-learning tasks were ... -
Computational Modelling of Blades for a Novel Wind Turbine
(Institute of Electrical and Electronics Engineers (IEEE), 2012-06)Blades of a novel wind turbine system based on the principles of impulse turbines were designed in 3D and tested by computational fluid dynamics (CFD) simulation. This new turbine system is suitable to construct on the ... -
Computational Modelling of Information Processing in Deep Cerebellar Nucleus Neurons
(2012-06-21)The deep cerebellar nuclei (DCN) function as output gates for a large majority of the Purkinje cells of the cerebellar cortex and thereby determine how the cerebellum influences the rest of the brain and body. In my PhD ... -
Computational Modelling of the Neural Systems Involved in Schizophrenia
(2008-04-01)The aim of this thesis is to improve our understanding of the neural systems involved in schizophrenia by suggesting possible avenues for future computational modelling in an attempt to make sense of the vast number of ... -
Computational modelling reveals contrasting effects on reinforcement learning and cognitive flexibility in stimulant use disorder and obsessive-compulsive disorder : remediating effects of dopaminergic D2/3 receptor agents
(2019-08-01)RATIONALE: Disorders of compulsivity such as stimulant use disorder (SUD) and obsessive-compulsive disorder (OCD) are characterised by deficits in behavioural flexibility, some of which have been captured using probabilistic ... -
Computational Models of Intracellular Signalling and Synaptic Plasticity Induction in the Cerebellum
(University of Hertfordshire, 2013-09-03)Many molecules and the complex interactions between them underlie plasticity in the cerebellum. However, the exact relationship between cerebellar plasticity and the different signalling cascades remains unclear. ... -
Computational optimization of CH4/H2/CO blends in a spark-ignition engine using quasi-dimensional combustion model
(2021-11-01)Recent research has proven that computational fluid dynamics (CFD) modeling in combination with a genetic algorithm (GA) algorithm is an effective methodology to optimize the design of internal combustion (IC) engines. ... -
Computational Properties of Cell Regulatory Pathways through Petri Nets
(Springer Nature, 2016-03)The paper develops a Petri net model of a negative feedback oscillator, Case 2a from Tyson et al. (Curr. Opin. Cell Biol. 15, 221–231, 2003), in order to be able to perform the holonomy decomposition of the automaton derived ...