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Now showing items 15348-15367 of 24095
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A novel role for peptidylarginine deiminases in microvesicle release reveals therapeutic potential of PAD inhibition in sensitizing prostate cancer cells to chemotherapy
(2015-06-22)Introduction: Protein deimination, defined as the post-translational conversion of protein-bound arginine to citrulline, is carried out by a family of 5 calcium-dependent enzymes, the peptidylarginine deiminases (PADs) and ... -
Novel selective compounds for the investigation of imidazoline receptors
(1999-06)Over several years our group has sought to synthesize and identify selective ligands for imidazoline (I) receptors, in particular the I2 binding site. As a consequence, [3H]2-(2-benzofuranyl)-2-imidazoline (2BFI) has proved ... -
A novel self-sintering microparticle-based system for regenerative medicine
(2008-07)The use of injectable scaffolds has raised great interest as they minimise the need for invasive surgery and its associated complications, costs and discomfort to the patient. Furthermore, they can fill cavities of any ... -
Novel Siglec-15-Sia axis inhibitor leads to colorectal cancer cell death by targeting miR-6715b-3p and oncogenes
(2023-10-06)Siglecs are well known immunotherapeutic targets in cancer. Current checkpoint inhibitors have exhibited limited efficacy, prompting a need for novel therapeutics for targets such as Siglec-15. Presently, small molecule ... -
A Novel Signal Processing Method for Friction and Sliding Wear
(2022-05-01)This current study proposed a new computationally efficient and comparatively accurate algorithm for calculating both static and dynamic coefficients of friction from high frequency data. Its scope embraced an application ... -
Novel stem cell technologies are powerful tools to understand the impact of human factors on Plasmodium falciparum malaria
(2023-12-19)Plasmodium falciparum parasites have a complex life cycle, but the most clinically relevant stage of the disease is the invasion of erythrocytes and the proliferation of the parasite in the blood. The influence of human ... -
Novel Synthetic Opioids (NSO) Use in Opioid Dependents Entering Detoxification Treatment
(2022-06-01)Introduction: Over the last decade, the use of New/Novel Synthetic Opioids (NSO) has emerged as an increasing problem, and especially so in the USA. However, only little is known about the prevalence and history of NSO use ... -
Novel systems to study vector-pathogen interactions in malaria
(2023-05-26)Some parasitic diseases, such as malaria, require two hosts to complete their lifecycle: a human and an insect vector. Although most malaria research has focused on parasite development in the human host, the life cycle ... -
A Novel Technique for Identifying Environmental Outcomes from Agricultural Practices
(2011-03)There are a wide range of techniques that can be used for evaluating environmental impacts of agriculture, but they have not previously been used to identify the contribution individual farming activities make toward ... -
A novel treatment strategy for preterm birth: Intra-vaginal progesterone-loaded fibrous patches
(2020-10-15)Progesterone-loaded poly(lactic) acid fibrous polymeric patches were produced using electrospinning and pressurized gyration for intra-vaginal application to prevent preterm birth. The patches were intravaginally inserted ... -
Novel Viroid‐Like RNAs Naturally Infect a Filamentous Fungus
(2022-12-14)To date, viroids have been found to naturally infect only plants, resulting in substantial losses for some crops. Whether viroids or viroid‐like RNAs naturally infect non‐plant hosts remains unknown. Here the existence of ... -
A Novel Visual Interface to Foster Innovation in Mechanical Engineering and Protect from Patent Infringement
(2018-04-25)One of the main time and money consuming tasks in the design of industrial devices and parts is the checking of possible patent infringements. Indeed, the great number of documents to be mined and the wide variety of ... -
Novel Ylidic Phosphoryl Compounds from Halogenated Furan-2,5-Diones with Trivalent Phosphorus Esters: Application of this Approach to New Trisphosphonates Containing a Geminal Bisphosphonate Unit
(2014-08-03)The reactions of trivalent phosphorus esters, including trialkyl phosphites, dialkyl phosphonites, and alkyl phosphinites, with 3-halo- and 3,4-dihalo-furan-2,5-diones has been shown to lead to the formation of novel ... -
Novelty detection in a Kohonen-like network with a long-term depression learning rule
(2003-06)In the cerebellar cortex, long-term depression (LTD) of synapses between parallel fibers (PF) and Purkinje neurons can spread to neighboring ones, independently of their activation by PF input. This spread of non-specific ... -
De novo assembly of the Pasteuria penetrans genome reveals high plasticity, host dependency, and BclA-like collagens
(University of Hertfordshire, 2018-12-04)Pasteuria penetrans is a gram-positive endospore forming bacterial parasite of Meloidogyne spp. the most economically damaging genus of plant parasitic nematodes globally. The obligate antagonistic nature of P. penetrans ... -
De novo ligand design to partially flexible active sites : Application of the Reflex algorithm to carboxypeptidase A, acetylcholinesterase, and the estrogen receptor
(2008-02)Reflex is a recent algorithm in the de novo ligand design software, SkelGen, that allows the flexibility of amino acid side chains in a protein to be taken into account during the drug-design process. In this paper the ...