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Browsing by Author "Keating, Christopher"
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Afferent hypersensitivity in a mouse model of post-inflammatory gut dysfunction : role of altered serotonin metabolism
Keating, Christopher; Beyak, M.; Foley, S.; Singh, G.; Marsden, C.; Spiller, R.; Grundy, D. (2008-09)Visceral hypersensitivity is an important clinical feature associated with irritable bowel syndrome which in some patients has been linked to prior infection. Here we employ an animal model in which transient infection ... -
Ageing and gastrointestinal sensory function : altered colonic mechanosensory and chemosensory function in the aged mouse
Keating, Christopher; Grundy, David (2015)Ageing has a profound effect upon gastrointestinal function through mechanisms that are poorly understood (1). A feature of ageing is impaired sensory perception, including a diminished sensory response to inflammatory ... -
Ageing and Gastrointestinal Sensory Function : The Enteric Nervous System
Keating, Christopher; Grundy, David (2016-07-06)Over the past few decades a combination of electrophysiological, morphological and molecular approaches has enabled the different populations of vagal and spinal afferents that innervate the bowel to be characterized. The ... -
Ageing and gastrointestinal sensory function: altered colonic mechanosensory and chemosensory function in the aged mouse.
Keating, Christopher; Nochi, Linda; Yu, Yang; Donovan, Jemma; Grundy, D (2016-08-14)Ageing has a profound effect upon gastrointestinal function through mechanisms that are poorly understood. Here we investigated the effect of age upon gastrointestinal sensory signalling pathways in order to address the ... -
Deoxycholic acid activates colonic afferent nerves via 5-HT3 receptor dependent and independent mechanisms
Yu, Yang; Villalobos- Hernandez, Egina; Pradhananga, Sabindra; Baker, Corey; Keating, Christopher; Grundy, David; Lomax, Allan; Reed, David (2019-09-01)Increased bile acids in the colon can evoke increased epithelial secretion resulting in diarrhea, but little is known about whether colonic bile acids contribute to abdominal pain. This study aimed to investigate the ... -
Differential modulation of motor neurons that innervate the same muscle but use different excitatory transmitters in Aplysia
Keating, Christopher; Lloyd, Philip (1999-10)The medial portion of intrinsic buccal muscle 3 (I3m) is innervated by two excitatory motor neurons, B3 and B9. B3 uses glutamate as its fast transmitter and expresses the neuropeptide FMRFamide, whereas B9 uses acetylcholine ... -
Dopamine induces hyperpolarization of locust salivary gland acinar cells via D1-like receptors.
Keating, Christopher; Orchard, Ian (2001-07)The effect of dopamine on the salivary gland acinar cells of the locust was examined using conventional intracellular recording techniques. Application of dopamine induced a reversible, dose-dependent hyperpolarization of ... -
The effect of prolonged CLP-induced sepsis on jejunal mesenteric afferent nerve activity in mice
Nullens, Sarah; Deiteren, Annemie; de Man, Joris; Keating, Christopher; Jiang, Wen; Grundy, D.; de Winter, Benedicte (2015-06) -
The effects of dopamine agonists and antagonists on the secretory responses in the salivary glands of the locust (Locusta migratoria)
Keating, Christopher; Orchard, Ian (2004-01)A study has been made on the effect of dopamine on salivary gland secretion rates from isolated locust salivary glands. Application of dopamine induced a concentration-dependent secretion with an IC50 of approximately 0.3 ... -
Extrinsic Sensory Afferent Nerves Innervating the Gastrointestinal Tract
Beyak, M; Bulmer, D; Jiang, W; Keating, Christopher; Rong, W; Grundy, D (McGraw-Hill, 2006) -
The FMRFamide-like AF2 is present in the parasitic nematode Haemonchus contortus
Keating, Christopher; Holden-Dye, Lindy; Thorndyke, Michael C.; Williams, R.G.; Mallett, A.; Walker, Robert J. (1995-11)Peptides belonging to the FMRFamide family are widely distributed amongst invertebrates. We report here on the isolation of the FMRFamide neuropeptide AF2 (Lys-His-Glu-Tyr-Leu-Arg-Phe-NH2) from the parasitic nematode ... -
In vitro recording of mesenteric afferent nerve activity in jejunal and colonic segments from rodents
Nullens, Sarah; Deiteren, Annemie; Jiang, Wen; Keating, Christopher; Ceuleers, Hannah; Franque, Sven; Grundy, David; de Man, Joris de Man; de Winter, Benedicte (2016-10-25)Afferent nerves not only convey information concerning normal physiology, but also signal disturbed homeostasis and pathophysiological processes of the different organ systems from the periphery towards the central nervous ... -
Intestinal Secretory and Absorptive Function in the Trichinella spiralis mouse model of Post-Infective Gut Dysfunction : role of bile acids
Kalia, N.; Hardcastle, J.; Grassi, Laura; Keating, Christopher; Pelegrin, Pablo; Bardhan, K.D.; Grundy, David (2008)Objective: Observations showing that bile acid malabsorption is frequent in irritable bowel syndrome (IBS) suggest that alterations in bile acid-induced secretion and absorption could contribute to IBS-associated diarrhoea. ... -
Investigation of the mode of action of nematode neuropeptides
Keating, Christopher; Holden-Dye, Lindy; Walker, Robert J. (1996-03)The neuropeptide AF2 has a complex set of actions on the dorsal muscle strip of Ascaris suum, including a potentiation of the acetylcholine-stimulated muscle contraction. Caffeine at 100 μm and 5 mm inhibited this potentiation, ... -
Mechanisms contributing to visceral hypersensitivity : focus on splanchnic afferent nerve signalling
Deiteren, Annemie; de Man, Joris; Keating, Christopher; Jiang, Wen; de Schepper, Heiko; Pelckmans, Paul; Francque, Sven; de Winter, Benedicte (2015-11-19)Visceral hypersensitivity is a main characteristic of functional bowel disorders and is mediated by both peripheral and central factors. We investigated whether enhanced splanchnic afferent signaling in vitro is associated ... -
Metabolism of AF1 (KNEFIRF-NH2) in the nematode, Ascaris suum, by aminopeptidases, endopeptidase and deaminase enzymes
Sajid, Mohammed; Keating, Christopher; Holden-Dye, Lindy; Harrow, Ian D.; Isaac, R.Elwyn (1996-01)We have studied the metabolism and inactivation of AF1 (KNEFIRF-NH2) by membranes prepared from the locomotory muscle of Ascaris suum. FIRF-NH2, NEFIRF-NH2 and KNEFIRF were identified as three primary degradation products, ... -
P2X 7 receptor-dependent intestinal afferent hypersensitivity in a mouse model of postinfectious irritable bowel syndrome
Keating, Christopher; Pelegrin, P.; Martínez, C.M.; Grundy, D. (2011-08-01)The ATP-gated P2X7 receptor (P2X7R) was shown to be an important mediator of inflammation and inflammatory pain through its regulation of IL-1β processing and release. Trichinella spiralis-infected mice develop a ... -
Post-infectious visceral hypersensitivity persists in the TRPV1 knockout mouse
Keating, Christopher; Grundy, David (2009-05) -
Purinergic contribution to small intestinal afferent hypersensitivity in a murine model of post infectious bowel disease.
Rong, Weifang; Keating, Christopher; Sun, B.; Dong, L.; Grundy, David (2009-06)Increased sensitivity of the afferent innervation of the gastrointestinal tract reportedly underlies symptoms of discomfort and pain in functional bowel disorders. The present investigation aimed to examine whether the ... -
Study of the mechanisms contributing to visceral hypersensitivity in a rat model of acute and postinflammatory colitis : focus on splanchnic afferent nerve signaling
Deiteren, Annemie; de Man, Joris de Man; Keating, Christopher; Jiang, Wen; Pelckmans, Paul; de Winter, Benedicte (2015-06)