Search
Now showing items 51-60 of 106
Stereospecific pharmacodynamics and pharmacokinetics of carprofen in the dog
(1994-12)
The non-steroidal anti-inflammatory drug (NSAID) carprofen (CPF) contains a single chiral centre. It was administered orally to Beagle dogs as a racemate (rac-CPF) at a dose of 4 mg per kg body weight and as individual ...
Chemotherapy and delivery systems - helminths
(1994-08)
The milbemycins are the only novel broad spectrum anthelmintic chemicals to reach the market place in the last 10 years. Many new systems for delivery and strategies for rational use have, however, been introduced. Boluses ...
Plasma disposition of amikacin and interactions with gastrointestinal microflora in Equidae following intravenous and oral administration
(1994-08)
Amikacin was detectable (> 0.02 micrograms/ml) in plasma for 12 h in horses and donkeys and for 8 h in ponies following intravenous (i.v.) administration at a dose rate of 6 mg/kg bodyweight. The elimination half-life ...
Pharmacodynamics and pharmacokinetics of carprofen in the horse.
(1994-05)
The pharmacokinetics and pharmacodynamics of the nonsteroidal anti-inflammatory drug (NSAID) carprofen have been evaluated in 6 horses using a model of acute non-immune inflammation. Following intravenous administration ...
Pharmacodynamics of tolfenamic acid in dogs : Evaluation of dose response relationships
(1994-03-03)
Tolfenamic acid was administered to beagle dogs at 2, 4 and 8 mg/kg bodyweight i.m. and the concentration of drug in plasma and in inflamed (administered carrageenan) and non-inflamed subcutaneous tissue cage fluid was ...
Ampicillin and its congener prodrugs in the horse
(1994-03)
Ampicillin is an antibiotic commonly administered to horses by both the intramuscular (i.m.) and the intravenous (i.v.) route. Its physicochemical properties restrict its absorption after oral administration and explain ...
The influence of Ostertagia circumcincta and Trichostrongylus colubriformis infections on the pharmacokinetics of febantel in lambs
(1993-09)
Plasma concentrations of febantel and its major metabolites fenbendazole, oxfendazole and oxfendazole sulphone were determined after oral administration of 7.5 mg/kg febantel in lambs before and 28 days after infection ...
Pharmacokinetics and clinical effects in dogs of a sustained-release formulation of theophylline
(1993-08)
Theophylline was administered orally in a sustained-release preparation at a dose rate of 20 mg/kg bodyweight to six beagle dogs. A mean (+/- se) maximum plasma concentration of 12.2 +/- 0.65 micrograms/ml was obtained ...
Interactions of Ostertagia species with their bovine and ovine hosts
(1993-07)
Ostertagia spp. affect their hosts in several complex interactions involving structural, biochemical, hormonal, nutritional and immunological mechanisms. Following infection with Ostertagia spp. the specialised secretory ...
Oral absorption and bioavailability of fenbendazole in the dog and the effect of concurrent ingestion of food
(1993-06)
Fenbendazole was administered orally without food to six beagle dogs at 2.5, 5.0, 10, 20, 40 and 80 mg/kg of body weight. Increasing the dose rate did not significantly increase the amount of fenbendazole absorbed. In a ...