Browsing by Title
Now showing items 11127-11146 of 24380
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In search of relevance : Is there an academic-practitioner divide in business-to-business marketing?
(2004)This article reports on three related empirical studies of the relevance of academic research to management practice in the field of business-to-business marketing. These studies comprise a survey of 58 academic researchers, ... -
In search of sustainable CAP: : Assessing the environmental impacts of agricultural policy
(1998)Agricultural policy can have a major influence on the environmental impacts of agriculture. As farming is a major land use in European Union (EU) these impacts can be significant and widespread. A scoring technique has ... -
In Search of Time, Eli Broad Art Museum, USA : Exhibition [Video and photographic installation]
(2012-11-09)In Search of Time (ISOT) was a curatorial project at the new Eli and Edythe Broad Art Museum, conceived by the international writer and curator Michael Rush of (‘Video Art’ 2007, ‘New Media in Art’ 2005 and ‘New Media in ... -
In Silico and In Vitro Investigation into the Next Generation of New Psychoactive Substances
(2019-03-29)New Psychoactive Substances (NPS) were designed to be legal alternatives to existing established recreational drugs. They have fast become a very popular and up until 2016, NPS were legal, cheap and freely accessible via ... -
In Silico and In Vitro Mapping of Receptor-Type Protein Tyrosine Phosphatase Receptor Type D in Health and Disease: Implications for Asprosin Signalling in Endometrial Cancer and Neuroblastoma
(2024-01-30)Background: Protein Tyrosine Phosphatase Receptor Type D (PTPRD) is involved in the regulation of cell growth, differentiation, and oncogenic transformation, as well as in brain development. PTPRD also mediates the effects ... -
In silico investigation of novel compounds as inhibitors of Acetylcholinesterase enzyme for the treatment of Alzheimer’s diseases
(2024-02-08)Alzheimer’s disease (AD) is a “progressive, neurodegenerative disease that occurs when nerve cells in the brain die.” There are only 4 drugs approved by the United States Food and Drug Administration (FDA). Three (donepezil, ... -
In Silico Investigations into the Selectivity of Psychoactive and New Psychoactive Substances in Monoamine Transporters
(2022-11-01)New psychoactive substances (NPS) are a group of compounds that mimic the effects of illicit substances. A range of NPS have been shown to interact with the three main classes of monoamine transporters (DAT, NET, and SERT) ... -
In silico methods for predicting ligand binding determinants of cytochromes P450
(2004)A large number of computational methodologies have been used to predict, and thus help explain, the metabolism catalysed by the enzymes of the cytochrome P450 superfamily (P450s). A summary of the methodologies and resulting ... -
In silico modelling of prostacyclin and other lipid mediators to nuclear receptors reveal novel thyroid hormone beta receptor antagonist properties.
(2016-01-01)Prostacyclin (PGI2) is a key mediator involved in cardiovascular homeostasis, acting predominantly on two receptor types; cell surface IP receptor and cytosolic peroxisome proliferator activated receptor (PPAR) β/δ. Having ... -
In Silico Prediction of Aqueous Solubility Using Simple QSPR Models : The Importance of Phenol and Phenol-like Moieties
(2012-10-28)Recently the authors published a robust QSPR model of aqueous solubility which exploited the computationally derived molecular descriptor topographical polar surface area (TPSA) alongside experimentally determined melting ... -
In silico screening for antibiotic escort molecules to overcome efflux
(2011-11-01)Resistance to antibiotics is a growing problem worldwide and occurs in part due to the overexpression of efflux pumps responsible for the removal of antibiotics from bacterial cells. The current study examines complex ... -
In silico structural evaluation of short cationic antimicrobial peptides
(2018-06-21)Cationic peptides with antimicrobial properties are ubiquitous in nature and have been studied for many years in an attempt to design novel antibiotics. However, very few molecules are used in the clinic so far, sometimes ... -
In silico studies on recreational drugs: 3D quantitative structure activity relationship prediction of classified and de novo designer benzodiazepines
(2023-01-30)Currently, increasing availability and popularity of designer benzodiazepines (DBZDs) constitutes a primary threat to public health. To assess this threat, the biological activity/potency of DBZDs was investigated using ... -
In situ aerosol characterization at Cape Verde. Part 2 : Parametrization of relative humidity- and wavelength-dependent aerosol optical properties
(2011-09-01)An observation-based numerical study of humidity-dependent aerosol optical properties of mixed marine and Saharan mineral dust aerosol is presented. An aerosol model was developed based on measured optical and microphysical ... -
In situ and Ex situ analysis of salmeterol xinafoate microcrystal formation from poly(ethylene glycol) 400 - Water cosolvent mixtures
(2008-06)Salmeterol xinafoate (SX) crystallization was investigated under different conditions of stirring, antisolvent addition, and supersaturation to identify factors limiting particle growth to enable the production of respirable ... -
In situ gelling drug delivery systems for topical drug delivery
(2023-01-13)In situ gelling formulations are drug delivery systems which typically exist in a liquid form at room temperature and change into gel state after application to the body in response to various stimuli such as changes in ... -
In situ gelling hydrogels incorporating microparticles as drug delivery carriers for regenerative medicine
(2008-09)Aqueous solutions of blends of biodegradable triblock copolymers, composed of poly(DL-lactide-co-glycolide) (PLGA) and poly(ethylene glycol) (PEG) with varied D,L-lactide to glycolide ratios, displayed thermosensitivity ... -
In situ preparation of copper-matrix composites
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In situ self assembly of soft diclofenac loaded microparticles in superstructured fluids
(2013-09)This study investigated how the in situ construction and payload delivery from soft diclofenac loaded hydroxypropylmethylcellulose (HPMC) coated microparticles was influenced by the superstructure of the cosolvent in which ...