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Now showing items 17024-17043 of 24095
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Poly (glycerol adipate) (PGA), an enzymatically synthesized functionalizable polyester and versatile drug delivery carrier : A literature update
(2019-09-25)The enzymatically synthesized poly (glycerol adipate) (PGA) has demonstrated all the desirable key properties required from a performing biomaterial to be considered a versatile "polymeric-tool" in the broad field of drug ... -
Poly(N-isopropyl acrylamide) – poly(ethylene glycol) – poly(N-isopropyl acrylamide) as a thermoreversible gelator for topical administration
(2020-05-06)Poly(N-isopropyl acrylamide) – block– poly(ethylene glycol) – block– poly(N-isopropyl acrylamide) is known to exhibit a thermally-induced solution-to-gel transition in water, which may be exploited for biomedical applications. ... -
Poly(triazolyl methacrylate) glycopolymers as potential targeted unimolecular nanocarriers
(2019-10-29)Synthetic glycopolymers are increasingly investigated as multivalent ligands for a range of biological and biomedical applications. This study indicates that glycopolymers with a fine-tuned balance between hydrophilic sugar ... -
Poly-glutamic dendrimer-based conjugates for cancer vaccination - a computational design for targeted delivery of antigens
(2017-08-10)Computational techniques are useful to predict interaction models and molecular properties for the design of drug delivery systems, such as dendrimers. Dendrimers are hyperbranched macromolecules with repetitive building ... -
Polyamine regulation of nitric oxide production in LPS-activated macrophages
(European Communities, 1999)Polyamines are physiological cellular constituents essential for cell growth and differentiation, and regulate a multitude of cellular functions (1-4). Nitric oxide (NO) is an effector molecule in both the cardiovascular ... -
Polyelectrolyte nanoparticles with high drug loading enhance the oral uptake of hydrophobic compounds
(2006-05)In the pharmaceutical industry, orally active compounds are required to have sufficient water solubility to enable dissolution within the gastrointestinal tract prior to absorption. Limited dissolution within the ... -
Polymer architecture dictates thermoreversible gelation in engineered emulsions stabilised with branched copolymer surfactants
(2022-09-26)The generation of materials that switch from a liquid to gel state upon warming can enable new healthcare technologies with improved functionality, such as in situ gel-forming materials for drug delivery to topical or ... -
Polymer Architecture Effects on Poly(N,N‐Diethyl Acrylamide)‐b‐Poly(Ethylene Glycol)‐b‐Poly(N,N‐Diethyl Acrylamide) Thermoreversible Gels and Their Evaluation as a Healthcare Material
(2021-12-11)Thermoreversible gels which transition between liquid‐like and solid‐like states when warmed have enabled significant novel healthcare technologies. Poly(N,N‐diethyl acrylamide) (PDEA) is a thermoresponsive polymer which ... -
Polymerase Chain Reaction
(Humana Press, 1998) -
A polymerase chain reaction (PCR) assay for the detection of inoculum of Sclerotinia sclerotiorum
(2002-11)The development of a polymerase chain reaction (PCR) assay for the detection of inoculum of the plant pathogenic fungus Sclerotinia sclerotiorum is described. The PCR primers were designed using nuclear ribosomal DNA ... -
Polymeric gels for intravaginal drug delivery
(2018-01-28)Intravaginal drug delivery can elicit a local effect, or deliver drugs systemically without hepatic first pass metabolism. There are a number of emerging areas in intravaginal drug delivery, but the vagina is a challenging ... -
Polymeric microcapsules with switchable mechanical properties for self-healing concrete : Synthesis, characterisation and proof of concept
(2017-03-14)Microcapsules, with sodium silicate solution as core, were produced using complex coacervation in a double, oil-in-water-in oil, emulsion system. The shell material was a gelatin-acacia gum crosslinked coacervate and the ... -
Polymeric Nanoparticles
(Springer Nature, 2013)Self-assembling polymers, which are either amphiphilic block copolymers with hydrophobic and hydrophilic blocks, hydrophilic polymer backbones substituted with hydrophobic units or polymers with a low aqueous solubility, ... -
Polymers exhibiting lower critical solution temperatures as a route to thermoreversible gelators for healthcare
(2020-11-20)The ability to trigger changes to material properties with external stimuli, so-called “smart” behavior, has enabled novel technologies for a wide range of healthcare applications. Response to small changes in temperature ... -
Polymorphic control of inhalation microparticles prepared by crystallization
(2008-09-01)Milling processes are known to cause polymorphic transition in enantiotropic systems and the micronization process employed to produce microparticles for inhalation formulations has been reported to result in solid-state ... -
Polymorphisms of the cannabinoid 1 receptor gene and cognitive impairment in multiple sclerosis
(2008)Cognitive impairment occurs in 45—65% of multiple sclerosis (MS) patients. The cannabinoid system may potentially be neuroprotective in MS. We examined the relationship between polymorphisms of the CNR1 gene and ... -
Polymycovirus Infection Sensitizes Aspergillus fumigatus for Antifungal Effects of Nikkomycin Z
(2023-01-10)Infection with Aspergillus fumigatus polymycovirus 1 (AfuPmV-1) weakens resistance of Aspergillus fumigatus common reference strain Af293 biofilms in intermicrobial competition with Pseudomonas aeruginosa. We compared the ... -
The polymycovirus-mediated growth enhancement of the entomopathogenic fungus Beauveria bassiana is dependent on carbon and nitrogen metabolism
(2021-02-02)Polymycoviridae is a growing family of mycoviruses whose members typically have non-conventional capsids and multi-segmented, double-stranded (ds) RNA genomes. Beauveria bassiana polymycovirus (BbPmV) 1 is known to enhance ...